June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Evaluation of correlation between Diopsys® NOVA fixed-luminance flicker electroretinography and Diagnosys® full-field electroretinography
Author Affiliations & Notes
  • Jonathan Regenold
    Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, United States
  • Hien Luong Doan
    Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, United States
    Truong Dai hoc Y khoa Pham Ngoc Thach, Ho Chi Minh, Ho Chi Minh, Viet Nam
  • Amir Akhavanrezayat
    Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, United States
  • Muhammad Sohail Halim
    Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, United States
    Ocular Imaging Research and Reading Center (OIRRC), Sunnyvale, California, United States
  • Azadeh Mobasserian
    Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, United States
  • Jaclyn Joyce Hwang
    Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, United States
  • Negin Yavari
    Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, United States
  • Vahid Bazojoo
    Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, United States
  • Wataru Matsumiya
    Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, United States
  • Irmak Karaca
    Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, United States
  • Brandon Pham
    Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, United States
  • Brandon Chau Lam
    Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, United States
  • Hassan Khojasteh
    Farabi Eye Hospital, Tehran, Tehran, Iran (the Islamic Republic of)
  • Sherin Lajevardi
    Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, United States
  • Diana V Do
    Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, United States
  • Quan Dong Nguyen
    Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, United States
  • Footnotes
    Commercial Relationships   Jonathan Regenold, None; Hien Doan, None; Amir Akhavanrezayat, None; Muhammad Sohail Halim, None; Azadeh Mobasserian, None; Jaclyn Hwang, None; Negin Yavari, None; Vahid Bazojoo, None; Wataru Matsumiya, None; Irmak Karaca, None; Brandon Pham, None; Brandon Lam, None; Hassan Khojasteh, None; Sherin Lajevardi, None; Diana Do, None; Quan Nguyen, None
  • Footnotes
    Support  Diopsys, an unrestricted grant from Research to Prevent Blindness, and the National Eye Institute P30-EY026877
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 611. doi:
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      Jonathan Regenold, Hien Luong Doan, Amir Akhavanrezayat, Muhammad Sohail Halim, Azadeh Mobasserian, Jaclyn Joyce Hwang, Negin Yavari, Vahid Bazojoo, Wataru Matsumiya, Irmak Karaca, Brandon Pham, Brandon Chau Lam, Hassan Khojasteh, Sherin Lajevardi, Diana V Do, Quan Dong Nguyen; Evaluation of correlation between Diopsys® NOVA fixed-luminance flicker electroretinography and Diagnosys® full-field electroretinography. Invest. Ophthalmol. Vis. Sci. 2021;62(8):611.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Diopsys® NOVA is a novel full-field electroretinography (ffERG) device with the ability to make rapid measurements of retinal electrophysiologic function. Diagnosys® ffERG is a clinical gold-standard ffERG device that can take upwards of four hours to make measurements. The purpose of this study was to investigate whether Diopsys® NOVA fixed-luminance flicker ffERG magnitude measurements correlate with amplitude measurements of Diagnosys® 30 Hz flicker ffERG.

Methods : Eighteen patients (36 eyes) with a variety of retinal diseases were subjected to conventional 30 Hz flicker ffERG followed by Diopsys® NOVA fixed-luminance flicker ffERG. Diopsys® magnitude measurements were compared to conventional ffERG amplitude measurements, and a Pearson correlation was used to evaluate any existing correlation. A Bland-Altman plot was also utilized to determine agreement between ffERG modules.

Results : Mean age of patients was 51.3 ± 22.7 years old. 67% of patients were female. The average Diopsys® magnitude measurement was 9.79 ± 5.20 µV while the average Diagnosys® amplitude measurement was 56.77 ± 31.85 µV. A significant, positive correlation (r=0.936, P<0.001) was observed between magnitude (Diopsys®) and amplitude (Diagnosys®) measurements. All data points lay within ± 1.96 SD of the mean difference, and a negative bias of -46.98 µV for the Diopsys® NOVA fixed-luminance ffERG flicker measurements. As magnitude and amplitude increased, the difference between these values also increased.

Conclusions : There is a statistically significant positive correlation between values of Diopsys® NOVA fixed-luminance flicker ffERG amplitude and Diagnosys® 30 Hz flicker ffERG magnitude. Agreement between the two systems of measurement is also demonstrated. Additionally, the Diopsys® based measurements have a negative bias compared to those of the conventional, gold-standard ffERG machine. This negative bias can be attributed to the skin electrodes used by the Diopsys® NOVA device in lieu of conventional ffERG corneal electrodes. These results suggest that the rapid Diopsys® NOVA module can produce accurate information assessing limited retinal function.

This is a 2021 ARVO Annual Meeting abstract.

 

Bland-Altman Plot Comparing Diopsys® NOVA Fixed-Luminance Flicker ffERG Magnitude to Diagnosys® 30 Hz Flicker ffERG Amplitude

Bland-Altman Plot Comparing Diopsys® NOVA Fixed-Luminance Flicker ffERG Magnitude to Diagnosys® 30 Hz Flicker ffERG Amplitude

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