June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Longitudinal positional changes of anterior scleral canal opening versus Bruch's membrane opening during high myopia development in juvenile tree shrews
Author Affiliations & Notes
  • Mahmoud Tawfik KhalafAllah
    Vision Science Graduate Program, University of Alabama at Birmingham, Birmingham, Alabama, United States
  • Preston A. Fuchs
    Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States
  • Fred Nugen
    Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States
  • Mustapha El Hamdaoui
    Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States
  • Alexander Levy
    Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama, United States
  • Brian C Samuels
    Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States
  • Rafael Grytz
    Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States
  • Footnotes
    Commercial Relationships   Mahmoud KhalafAllah, None; Preston A. Fuchs, None; Fred Nugen, None; Mustapha El Hamdaoui, None; Alexander Levy, None; Brian Samuels, Heidelberg Engineering provided Spectralis OCT2 at no cost (F); Rafael Grytz, Heidelberg Engineering provided Spectralis OCT2 at no cost (F)
  • Footnotes
    Support  NIH Grants R01-EY027759, R01-EY026588, P30 EY003909; EyeSight Foundation of Alabama; Research to Prevent Blindness.
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 3273. doi:
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      Mahmoud Tawfik KhalafAllah, Preston A. Fuchs, Fred Nugen, Mustapha El Hamdaoui, Alexander Levy, Brian C Samuels, Rafael Grytz; Longitudinal positional changes of anterior scleral canal opening versus Bruch's membrane opening during high myopia development in juvenile tree shrews. Invest. Ophthalmol. Vis. Sci. 2021;62(8):3273.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate positional changes of the Bruch's membrane opening (BMO) relative to the anterior scleral canal opening (ASCO) during high myopia development in juvenile tree shrews.

Methods : Juvenile tree shrews were randomly assigned to two groups: normal visual experience (n=9) and monocular -10D lens treatment to induce high myopia, where the other eye served as a control (n=12). Lens treatment started at 24 days of visual experience (DVE). Refractive (Nidek ARK-700A, Marco Ophthalmic) and biometric (Lenstar LS-900, Haag-Streit) measurements were obtained daily. Optical coherence tomography (OCT) of optic nerve head (ONH) (Spectralis, Heidelberg Engineering) was performed weekly. BMO and ASCO were manually segmented and analyzed after nonlinear distortion correction (Grytz R, et al. IOVS 2020; 61: ARVO E-Abstract 4778) of each OCT scan.

Results : Offset between ASCO/BMO centroids gradually increased during axial elongation and high myopia development in the lens treated eyes. These positional changes were significantly different from control and normal eyes at 59 DVE (two-sided Wilcoxon rank sum test; 0.05 ± 1.9µm, -0.05 ± 1.4 µm and 3.46 ± 3.5 µm, mean ± SEM in normal, control and myopic eyes respectively; p<0.05). Largest changes in ASCO/BMO centroid offset occurred in myopic eyes towards the inferior-nasal quadrant with BMO points located outside the ASCO boundary. BMO/ASCO areas and ovality indices were not significantly different among the three groups.

Conclusions : Our results show relative deformations of BMO and ASCO that gradually increase during high myopia development in juvenile tree shrews. These morphological changes during juvenile myopia development may contribute to subsequent ONH remodeling and increased risk of glaucoma later in life.

This is a 2021 ARVO Annual Meeting abstract.

 

Figure 1: Development of axial length (A), refraction (B), and ASCO/BMO centroid offset change from baseline (C) for the normal, control and myopic eyes (error bars represent SEM). Representative OCT scans of one myopic eye with ASCO and BMO delineated at DVE 24 (D) and DVE 59 (F). E, G: Polar plots of ASCO and BMO of the same eye, where the green line shows the B-scan position in D, F. H: Change in ASCO/BMO centroid offset from baseline (S: superior; I: inferior; T: temporal; N: nasal). Solid lines connect the longitudinal data of individual eyes.

Figure 1: Development of axial length (A), refraction (B), and ASCO/BMO centroid offset change from baseline (C) for the normal, control and myopic eyes (error bars represent SEM). Representative OCT scans of one myopic eye with ASCO and BMO delineated at DVE 24 (D) and DVE 59 (F). E, G: Polar plots of ASCO and BMO of the same eye, where the green line shows the B-scan position in D, F. H: Change in ASCO/BMO centroid offset from baseline (S: superior; I: inferior; T: temporal; N: nasal). Solid lines connect the longitudinal data of individual eyes.

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