June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Location-specific patterns of inner retinal thinning in intermediate Age-related Macular Degeneration
Author Affiliations & Notes
  • Matt Trinh
    Centre for Eye Health Ltd, Kensington, New South Wales, Australia
    University of New South Wales, Sydney, New South Wales, Australia
  • Michael Kalloniatis
    Centre for Eye Health Ltd, Kensington, New South Wales, Australia
    University of New South Wales, Sydney, New South Wales, Australia
  • Lisa Nivison-Smith
    University of New South Wales, Sydney, New South Wales, Australia
    Centre for Eye Health Ltd, Kensington, New South Wales, Australia
  • Footnotes
    Commercial Relationships   Matt Trinh, None; Michael Kalloniatis, None; Lisa Nivison-Smith, None
  • Footnotes
    Support  Rebecca Cooper Foundation; National Health and Medical Research Council of Australia (NHMRC grant #1174385); Australian Research Training Program; Guide Dogs NSW/ACT
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 305. doi:
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    • Get Citation

      Matt Trinh, Michael Kalloniatis, Lisa Nivison-Smith; Location-specific patterns of inner retinal thinning in intermediate Age-related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2021;62(8):305.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To examine inner retinal thickness changes of intermediate age-related macular degeneration (iAMD) eyes using grid-wise cluster analysis for macular optical coherence tomography (OCT) volume scans.

Methods : OCT macular cube scans (30° × 25°) were acquired for 91 eyes with iAMD from 91 participants, and 91 sex- and age-similar normal eyes from 91 participants. Thicknesses of the retinal nerve fibre layer (RNFL), ganglion cell layer (GCL), and inner plexiform layer (IPL) were defined at 60-64 locations across an 8 × 8 grid (3° × 3° per grid) centred on the fovea. Previously developed topographical clusters, i.e. locations of isometric normative thicknesses, were used to define location-specific comparisons between iAMD and normal eyes.

Results : Location-specific analysis of iAMD versus normal eyes demonstrated various patterns of thickness changes in each inner retinal layer. The RNFL displayed no significant differences across the macula; the GCL displayed thinning towards the fovea (mean difference ± SEM: −1.63 ± 0.5% to −5.07 ± 1.07%, P < 0.01 to < 0.0001) and borderline thickening towards the peripheral macula (1.26 ± 0.48%, P < 0.01); the IPL displayed diffuse thinning (−2.23 ± 0.53% to −4.1 ± 0.74%, P < 0.001 to < 0.0001).

Conclusions : Location-specific thickness changes in the GCL and IPL support potential anterograde trans-synaptic degeneration in intermediate AMD, with sparing of the RNFL. These data may better guide clinical diagnosis and monitoring of intermediate AMD to include inner retinal measures.

This is a 2021 ARVO Annual Meeting abstract.

 

Comparison of cluster thicknesses between iAMD and normal eyes in the (A) RNFL, (C) GCL, (E) and IPL, displayed as box and whisker plots (extending to 5th and 95th percentiles). + = mean, horizontal line = median. Mean difference values are displayed beneath the x-axis as µm and % of the normal mean. Significance P values were calculated by multiple t-tests, denoted by: ns = P > 0.05, ** = P < 0.01, *** = P < 0.001, and **** = P < 0.0001, with values highlighted in red denoting significance below the Bonferroni-adjusted P value. (B, D, and F) demonstrate previously developed topographical clusters of individual retinal layer thicknesses (represented by distinct colours) corresponding to (A, C, and E) respectively. Clusters are in right eye format as demonstrated by the optic nerve location. Note the various patterns of thickness changes in each layer.
N, normal eyes; A, iAMD eyes

Comparison of cluster thicknesses between iAMD and normal eyes in the (A) RNFL, (C) GCL, (E) and IPL, displayed as box and whisker plots (extending to 5th and 95th percentiles). + = mean, horizontal line = median. Mean difference values are displayed beneath the x-axis as µm and % of the normal mean. Significance P values were calculated by multiple t-tests, denoted by: ns = P > 0.05, ** = P < 0.01, *** = P < 0.001, and **** = P < 0.0001, with values highlighted in red denoting significance below the Bonferroni-adjusted P value. (B, D, and F) demonstrate previously developed topographical clusters of individual retinal layer thicknesses (represented by distinct colours) corresponding to (A, C, and E) respectively. Clusters are in right eye format as demonstrated by the optic nerve location. Note the various patterns of thickness changes in each layer.
N, normal eyes; A, iAMD eyes

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