June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Longitudinal analysis of retinal microvascular changes and its association with diabetic retinopathy
Author Affiliations & Notes
  • Hassanain Qambari
    CSIRO Health and Biosecurity, Canberra, Australian Capital Territory, Australia
    The University of Western Australia, Perth, Western Australia, Australia
  • Sajib Kumar Saha
    CSIRO Health and Biosecurity, Canberra, Australian Capital Territory, Australia
  • Saptahrshi Seal
    CSIRO Health and Biosecurity, Canberra, Australian Capital Territory, Australia
  • Cirous Dehghani
    CSIRO Health and Biosecurity, Canberra, Australian Capital Territory, Australia
    University of Canberra, Canberra, Australian Capital Territory, Australia
  • Katie Edwards
    Queensland University of Technology, Brisbane, Queensland, Australia
  • Nicola Pritchard
    Queensland University of Technology, Brisbane, Queensland, Australia
  • Anthony Russell
    The University of Queensland, Saint Lucia, Queensland, Australia
  • Rayaz Malik
    The University of Manchester, Manchester, Manchester, United Kingdom
    Weill Cornell Medicine-Qatar, Qatar
  • Nathan Efron
    Queensland University of Technology, Brisbane, Queensland, Australia
  • Marc Tennant
    The University of Western Australia, Perth, Western Australia, Australia
  • Yogesan Kanagasingam
    The University of Notre Dame Australia, Fremantle, Western Australia, Australia
  • Shaun Frost
    CSIRO Health and Biosecurity, Canberra, Australian Capital Territory, Australia
  • Footnotes
    Commercial Relationships   Hassanain Qambari, None; Sajib Kumar Saha, None; Saptahrshi Seal, None; Cirous Dehghani, None; Katie Edwards, None; Nicola Pritchard, None; Anthony Russell, None; Rayaz Malik, None; Nathan Efron, None; Marc Tennant, None; Yogesan Kanagasingam, None; Shaun Frost, None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 1088. doi:
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      Hassanain Qambari, Sajib Kumar Saha, Saptahrshi Seal, Cirous Dehghani, Katie Edwards, Nicola Pritchard, Anthony Russell, Rayaz Malik, Nathan Efron, Marc Tennant, Yogesan Kanagasingam, Shaun Frost; Longitudinal analysis of retinal microvascular changes and its association with diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 2021;62(8):1088.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Diabetic retinopathy (DR) is the leading cause of blindness in the working-age population. Identifying early retinal microvascular changes relevant to DR has the potential to detect DR prior to physical manifestations in the eye. This study aims to determine a set of microvascular biomarkers that are responsible for the development and progression of DR.

Methods : A retrospective study cohort consisting of baseline and follow-up images of 30 healthy and 30 diabetic participants randomly chosen from the LANDMark study. Diagnosis of DR was based on Early Treatment of Diabetic Retinopathy Study scale. A set of 84 geometric microvascular parameters (GMP) were generated from macular centred images using a semi-automated, multi-step web-based Vascular AnalySis Program (VASP). VASP automatically identified vessel boundaries, categorized vessels into arteries or veins, and divided the fundus into multiple zones. An experienced grader confirmed and adjusted the outputs produced by VASP (when necessary), and GMPs were then generated. We analysed the four evolution of all 84 GMPs returned by VASP and compared each parameter between the two groups. Demographic comparisons were performed using a Chi x2 test and parameter analysis was performed using a Generalised Linear Model to correct for confounders.

Results : The mean age of diabetic cohort was 57 ± 11 years, with their average BMI significantly greater than the healthy cohort (28 ± 6 kg/m2, p=0.03). Supine systolic and diastolic blood pressure were significantly higher (p< 0.001 & 0.03) in diabetes. From the 84 generated GMPs, five were significantly different between the two groups. In relation to the diabetic cohort, these topographic differences can be summarised as: increased tortuosity for all vessels in Zone C (p=0.002), increased tortuosity thickness for arteries and veins in Zone B,C (p=0.02 & 0.03), increased asymmetric width ratio for vessel branches in Zone C (p=0.01), and the combined width of 2 major vein trees in Zone C increased (p=0.04).

Conclusions : Our study found a significant increase in five novel GMPs exclusive to diabetes. Following further research, these objective measurements could be used as biomarkers to identify patients at risk of developing referable DR and enable timely treatment, thus reducing the risk of blindness.

This is a 2021 ARVO Annual Meeting abstract.

 

Steps of parameter generation

Steps of parameter generation

 

GMPs compared across healthy and diabetic groups.

GMPs compared across healthy and diabetic groups.

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