June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Measurement of retinal sensitivity and directionality in myopes with modified microperimetry and multimodal imaging approach
Author Affiliations & Notes
  • Josselin Gautier
    Paris Eye Imaging, INSERM, Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris, Île-de-France, France
  • Kate Grieve
    Paris Eye Imaging, INSERM, Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris, Île-de-France, France
  • Michel Paques
    Paris Eye Imaging, INSERM, Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris, Île-de-France, France
  • Footnotes
    Commercial Relationships   Josselin Gautier, None; Kate Grieve, None; Michel Paques, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 3139. doi:
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    • Get Citation

      Josselin Gautier, Kate Grieve, Michel Paques; Measurement of retinal sensitivity and directionality in myopes with modified microperimetry and multimodal imaging approach. Invest. Ophthalmol. Vis. Sci. 2021;62(8):3139.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Nasal misalignment of cones toward the optic nerve head (ONH) in myopic eyes is believed to be associated with the greater length of the eyeball. However, both physiological explanations at the retinal level and functional evaluation of the practical, visual impact of this photoreceptor misalignment in the daily lives of myopic individuals are limited.

Methods : We developed two microperimetry multi-angle methods to measure the peak location and directionality known as the Stiles Crawford Effect type I (SCE-I). A clinical grade MAIA microperimeter presented Maxwellian-view background and test (Goldman size III) stimuli at various eccentricities, while compensating for eye movements. SCE-I functions were obtained from directional sensitivity measurements, either by controlled translation of the instrument or rotation of the eye, without and with background illumination, respectively. Displacement of the peak of the SCE-I function was compared to objective measurement of foveal axis alignment in relation to pupil entry point with Directional OCT.

Results : Myopic subjects (N = 4) unlike emmetropes (N=3) appeared to show irregular nasal contrast sensitivity, and nasal misalignment of the SCE-I peak toward the ONH. SCE-I functions were corroborated by directional OCT based foveal axis measurements.

Conclusions : The methods described here provide a rather fast and accessible way to measure photoreceptor alignment at various retinal locations, which could be important to characterize - and potentially better treat - functional visual losses experienced by individuals with myopia. Our next step will be to determine alignment of individual photoreceptors using high resolution imaging modalities.

This is a 2021 ARVO Annual Meeting abstract.

 

 

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