June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Ex vivo evaluation of the peripheral retina utilizing a mirrored contact with optical coherence tomography
Author Affiliations & Notes
  • Frank Brodie
    Duke University, Durham, North Carolina, United States
  • Ryan P McNabb
    Duke University, Durham, North Carolina, United States
  • William Raynor
    Duke University, Durham, North Carolina, United States
  • Jianwei David Li
    Duke University, Durham, North Carolina, United States
  • Lejla Vajzovic
    Duke University, Durham, North Carolina, United States
  • Joseph Izatt
    Duke University, Durham, North Carolina, United States
  • Cynthia A Toth
    Duke University, Durham, North Carolina, United States
  • Footnotes
    Commercial Relationships   Frank Brodie, Long Bridge Medical (P), Long Bridge Medical (I), Long Bridge Medical (C); Ryan McNabb, None; William Raynor, None; Jianwei Li, None; Lejla Vajzovic, Alcon (C); Joseph Izatt, Kirkland and Ellis LLP (C), Leica Microsystems (P), Leica Microsystems (R), St Jude Medical (P), St Jude Medical (R); Cynthia Toth, Alcon (I), EMME (C), Theia Imaging (I)
  • Footnotes
    Support  NIH Grant EY028079-03
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 3104. doi:
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      Frank Brodie, Ryan P McNabb, William Raynor, Jianwei David Li, Lejla Vajzovic, Joseph Izatt, Cynthia A Toth; Ex vivo evaluation of the peripheral retina utilizing a mirrored contact with optical coherence tomography. Invest. Ophthalmol. Vis. Sci. 2021;62(8):3104.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Many important retinal diseases that would benefit from evaluation with optical coherence tomography (OCT), such as retinal breaks and retinoschisis are frequently located in the peripheral retina. However, clinical OCT imaging is generally confined to capturing the posterior pole. We describe a new method for capturing OCT images of the peripheral retina using a mirrored contact lens.

Methods : An ex vivo porcine eye was set up for standard 25 gauge 3 port pars plana vitrectomy with the Alcon Accurus system (Fort Worth, TX). Using the Leica Proveo 8 with BIOM widefield viewing system (Wetzlar, Germany) we created a retinal break approximately 1 mm posterior to the ora serrata with the vitreous cutter.

Results : Transillumination of the break using the endoilluminator confirmed the peripheral location externally at 5 mm posterior to the limbus - Figure 1A. Using the microscope, we directly visualized the break with a Goldmann-type 3 mirror contact lens – Figure 1B. Our research surgical microscope-integrated OCT (MIOCT) system, consisting of a 400 kHz 1050 nm swept source engine, was directed through the Goldmann 66° mirror and captured B-scans of the retina. We were able to identify retinal vessels, normal peripheral retina and the iatrogenic break within the OCT images– Figure 1C.

Conclusions : Use of a mirrored contact lens to obtain OCT images of the peripheral retina is a promising new technique to evaluate peripheral retinal anatomy. It can be used to identify sites with and without retinal pathology in the periphery. Additionally, this technique has the potential to examine the vitreous base.

This is a 2021 ARVO Annual Meeting abstract.

 

Ex vivo porcine model: Peripheral location of the break with endoillumination (A). Direct visualization of the break (red arrow) with Goldmann lens (B). OCT directed through the Goldmann lens and 66° mirror showing the peripheral retinal break (C).

Ex vivo porcine model: Peripheral location of the break with endoillumination (A). Direct visualization of the break (red arrow) with Goldmann lens (B). OCT directed through the Goldmann lens and 66° mirror showing the peripheral retinal break (C).

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