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Muhammad Hassan, Sarakshi Mahajan, Maria Soledad Ormaechea, Rupesh V Agrawal, Quan Dong Nguyen, Ruwan Amila Silva; Effect of Photodynamic Therapy on Choroidal Indices in Patients with Central Serous Chorioretinopathy. Invest. Ophthalmol. Vis. Sci. 2021;62(8):2845.
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© ARVO (1962-2015); The Authors (2016-present)
To report the effect of photodynamic therapy (PDT) on choroidal indices in patients with central serous chorioretinopathy (CSC).
Patients with a confirmed diagnosis of CSC managed at a tertiary care center, who underwent PDT with subsequent resolution of the subretinal fluid were analyzed. The PDT procedure was performed by the same physician. Enhanced depth imaging optical coherence tomography (EDI-OCT) scans of the study population were captured and analyzed before and after the resolution of the subretinal fluid. 5-line high definition scans centered on the foveal center were utilized. Image J (Version 1.52a, NIH) was utilized to segment the choroidal layer in each of the b-scan to evaluate: 1) Subfoveal Choroidal Thickness (SFCT); 2) Choroidal Volume (CV); and 3) Choroidal Vascularity Index (CVI). Multiple linear regression was used to compare the choroidal indices at the two time points.
Six patients with a confirmed diagnosis of CSC that demonstrated resolution of subretinal fluid after receiving PDT were analyzed. The mean age of the study population was 62 (Range: 45-68 years). Five (83.33%) patients were male. The mean (SD) SFCT, CV, and CVI before the PDT of the study population was 310.35 (97.84), 1.64 (0.35), and 0.648 (0.009), respectively. Following the resolution of the subretinal fluid, the mean (SD) SFCT, CV, and CVI of the study population were 240.43 (95.25), 1.61 (0.31), and 0.649 (0.008), respectively. Multiple linear regression demonstrated a statistically significant decrease in SFCT (R2=91, p=0.045), CV (R2=97, p=0.021) and increase in CVI (R2=98, p=0.015) after PDT.
PDT is associated with significant changes in the choroidal structure in CSC patients. Choroidal indices may be employed to monitor disease progression.
This is a 2021 ARVO Annual Meeting abstract.
Figure 1: Mean changes in subfoveal choroidal thickness (SFCT), choroidal volume (CV), and choroidal vascularity index (CVI) pre- and post-photodynamic therapy (PDT) in patients with central serous chorioretinopathy (CSC)
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