June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Retinal Oximetry Revealed Glaucomatous Eyes Had Lower Retinal Metabolism Using Visible Light Optical Coherence Tomography (vis-OCT)
Author Affiliations & Notes
  • Zeinab Ghassabi
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
  • Behnam Tayebi
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
    Neuroscience Institute, NYU Langone Health, New York, New York, United States
  • Mengfei Wu
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
    Division of Biostatistics, Departments of Population Health and Environmental Medicine, NYU Langone Health, New York, New York, United States
  • Samantha Palmer
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
  • Ronald Zambrano
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
  • Johnny Li
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
  • Ian Rubinoff
    Department of biomedical Engineering, Northwestern University, Evanston, Illinois, United States
  • Roman V. Kuranov
    Department of biomedical Engineering, Northwestern University, Evanston, Illinois, United States
    Opticent Inc., Evanston, Illinois, United States
  • Yuanbo Wang
    Opticent Inc., Evanston, Illinois, United States
  • Gadi Wollstein
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
    Department of Biomedical Engineering, New York University Tandon School of Engineering, Brooklyn, New York, United States
  • Joel S Schuman
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
    Department of Biomedical Engineering, New York University Tandon School of Engineering, Brooklyn, New York, United States
  • Hao Zhang
    Department of biomedical Engineering, Northwestern University, Evanston, Illinois, United States
  • Hiroshi Ishikawa
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
    Department of Biomedical Engineering, New York University Tandon School of Engineering, Brooklyn, New York, United States
  • Footnotes
    Commercial Relationships   Zeinab Ghassabi, None; Behnam Tayebi, None; Mengfei Wu, None; Samantha Palmer, None; Ronald Zambrano, None; Johnny Li, None; Ian Rubinoff, None; Roman V. Kuranov, None; Yuanbo Wang, None; Gadi Wollstein, None; Joel Schuman, Zeiss (P); Hao Zhang, Opticent Inc (P), Opticent Inc (I); Hiroshi Ishikawa, None
  • Footnotes
    Support  NIH: R01-EY013178, P30EY013079, unrestricted grant from Research to Prevent Blindness
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 2526. doi:
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      Zeinab Ghassabi, Behnam Tayebi, Mengfei Wu, Samantha Palmer, Ronald Zambrano, Johnny Li, Ian Rubinoff, Roman V. Kuranov, Yuanbo Wang, Gadi Wollstein, Joel S Schuman, Hao Zhang, Hiroshi Ishikawa; Retinal Oximetry Revealed Glaucomatous Eyes Had Lower Retinal Metabolism Using Visible Light Optical Coherence Tomography (vis-OCT). Invest. Ophthalmol. Vis. Sci. 2021;62(8):2526.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To compare in vivo measurements of oxygen saturation (sO2) between healthy and glaucomatous eyes using visible-light optical coherence tomography (vis-OCT).

Methods : Eight eyes of 8 healthy volunteers and five eyes of 5 glaucoma age-matched patients were enrolled into our pilot study. For each eye, one pair of retinal major artery and vein in superior and inferior regions near the optic nerve head (Figure) were scanned during the same session with our prototype vis-OCT (8192 x 16 samplings in 1x1mm2). Spectroscopic analysis was performed using short-time Fourier transformation (STFT). Wavelength-dependent OCT amplitudes from the same depth location across adjacent A-lines, all within the blood vessels, were averaged and then fitted to hemoglobin absorption profile based on Beer-Lambert’s law. Highest artery and vein sO2 values in superior or inferior regions were recorded as the sO2 measurements for each eye. Wilcoxon’s paired signed rank test was used to compare the age-matched healthy and glaucomatous subjects. Correlation between vein sO2 and visual field mean deviation (MD) recorded at the same visits was calculated using Spearman correlation coefficient (r). Results were compared with conventional structural OCT measurements, retinal nerve fiber layer (RNFL) and ganglion cell inner plexiform layer (GCIPL) thickness measured using Cirrus HD-OCT (Zeiss, Dublin, CA).

Results : Table 1 and Table 2 show demographics and measurements on 5 age-matched pairs of healthy and glaucomatous eyes. Artery sO2 showed no difference between healthy and glaucomatous eyes, while vein sO2 was marginally higher in glaucomatous eyes than healthy eyes (Table 2). Vein sO2 and RNFL and GCIPL thicknesses all showed statistically significant correlation with MD (Table 3). When comparing the correlation between vein sO2, RNFL and GCIPL, no statistical difference was detected between any combination (Fisher’s paired test).

Conclusions : Glaucomatous eyes had marginally higher oxygen saturation in the veins compared to healthy eyes, while there was no difference in oxygen saturation in the arteries, suggesting less oxygen consumption in the retina with glaucomatous damage. Vis-OCT sO2 measurement may have a potential as a clinical glaucoma biomarker in parallel with RNFL and GCIPL thickness. Further study with a larger sample size is warranted.

This is a 2021 ARVO Annual Meeting abstract.

 

 

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