June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Ultra-high field functional MRI based population receptive field mapping of retinal dystrophies
Author Affiliations & Notes
  • Markus Ritter
    Department of Ophthalmology, Medizinische Universitat Wien, Wien, Wien, Austria
  • David Linhardt
    MR Center of Excellence, Center for Medical Physics and Biomedical Engineering, Medizinische Universitat Wien, Wien, Wien, Austria
  • Maximilian Pawloff
    Department of Ophthalmology, Medizinische Universitat Wien, Wien, Wien, Austria
  • Allan Hummer
    MR Center of Excellence, Center for Medical Physics and Biomedical Engineering, Medizinische Universitat Wien, Wien, Wien, Austria
  • Michael Woletz
    MR Center of Excellence, Center for Medical Physics and Biomedical Engineering, Medizinische Universitat Wien, Wien, Wien, Austria
  • Christian Windischberger
    MR Center of Excellence, Center for Medical Physics and Biomedical Engineering, Medizinische Universitat Wien, Wien, Wien, Austria
  • Ursula Schmidt-Erfurth
    Department of Ophthalmology, Medizinische Universitat Wien, Wien, Wien, Austria
  • Footnotes
    Commercial Relationships   Markus Ritter, None; David Linhardt, None; Maximilian Pawloff, None; Allan Hummer, None; Michael Woletz, None; Christian Windischberger, None; Ursula Schmidt-Erfurth, None
  • Footnotes
    Support  Austrian Science Fund (FWF) Grant KLI 670-B30
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 2311. doi:
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      Markus Ritter, David Linhardt, Maximilian Pawloff, Allan Hummer, Michael Woletz, Christian Windischberger, Ursula Schmidt-Erfurth; Ultra-high field functional MRI based population receptive field mapping of retinal dystrophies. Invest. Ophthalmol. Vis. Sci. 2021;62(8):2311.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Population receptive field (pRF) mapping methods allows mapping visual field losses due to retinal pathology, as recently shown in a study on retinal scotoma sizes at 3T. MRI scanners operating at ultra-high magnetic field (7 Tesla and above) offer increased sensitivity and specificity of brain activation maps, but also pose additional challenges in image acquisition and subject handling, particularly in clinical populations.

Methods : Ten eyes from 10 patients clinically and genetically diagnosed with Stargardt disease (STGD) (age: 29 ± 9.7; 4 female) were included in the study. Data was acquired on a 7 Tesla MAGNETOM scanner using a 32-channel head coil with 1mm isotropic resolution using the CMRR multi-band EPI sequence. Visual stimulus consisted of a moving, flickering bar covering the central 14° visual angle. In addition, patients were examined using optical coherence tomography (OCT, Heidelberg Spectralis) and microperimetry (MP-3, Nidek). Data was analyzed using mrVista to obtain retinotopic maps. Visual field coverage based on above-threshold voxels from the pRF-analysis allows for a direct comparison with retinal sensitivity maps as measured by MP.

Results : Four patients were excluded due to attention deficits or excessive movement during the MRI measurements. All remaining patients had framewise displacement (FD) values of 0.025±0.004 mm and 5068±2162 V1 voxel activated (mean±stddev). Figures show MP and pRF results of two exemplary patients with macular scotoma confined to the central 2° visual angle. It can clearly be seen that uncovered areas on the coverage maps obtained by ultra-high-field fMRI resemble areas with functional loss in MP.

Conclusions : This is the first demonstration of ultra-high field pRF mapping in patients with STGD. Coverage maps obtained from pRF data provide information complementary to conventional ophthalmic examination and allow for objective assessment of retinal dysfunction.

This is a 2021 ARVO Annual Meeting abstract.

 

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