June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Age-dependent Contribution of the Crystalline Lens to the Retinal Image Field Curvature
Author Affiliations & Notes
  • Fabrice Manns
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Department of Biomedical Engineering, University of Miami, Coral Gables, Florida, United States
  • Arthur Ho
    Brien Holden Vision Institute Limited, Sydney, New South Wales, Australia
    School of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales, Australia
  • Bianca Maceo Heilman
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Ashik Mohamed
    Ophthalmic Biophysics, LV Prasad Eye Institute, Hyderabad, Telangana, India
  • Marco Ruggeri
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Department of Biomedical Engineering, University of Miami, Coral Gables, Florida, United States
  • Jean-Marie A Parel
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Brien Holden Vision Institute Limited, Sydney, New South Wales, Australia
  • Footnotes
    Commercial Relationships   Fabrice Manns, None; Arthur Ho, None; Bianca Maceo Heilman, None; Ashik Mohamed, None; Marco Ruggeri, None; Jean-Marie Parel, None
  • Footnotes
    Support  NEI Grants: R01EY021834, F31EY021444 (Maceo), P30EY14801 (Center Grant); the Florida Lions Eye Bank and the Beauty of Sight Foundation; Research to Prevent Blindness; the Henri and Flore Lesieur Foundation (JMP); Hyderabad Eye Research Foundation; Ministerio de Educacion y Ciencia, Spain (FIS2017- 84753-bR); IMCUSTOMEYE Ref. 779960 (H2020-ICT-2017-1); Consejo Superior de Investigaciones Cientificas ICoop Program; donations from Drs. HW Flynn, KR Olsen and ME Hildebrandt, Raksha Urs and Aaron Furtado.
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 2011. doi:
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      Fabrice Manns, Arthur Ho, Bianca Maceo Heilman, Ashik Mohamed, Marco Ruggeri, Jean-Marie A Parel; Age-dependent Contribution of the Crystalline Lens to the Retinal Image Field Curvature. Invest. Ophthalmol. Vis. Sci. 2021;62(8):2011.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Defocus in the periphery of the retinal image field maybe a factor in refractive development. Peripheral defocus is generally attributed to changes in globe shape or axial length. However, age-related changes in crystalline lens shape and optics may also be a factor. The goal is to quantify the lens contribution to the shape of the retinal image field and its changes with age.

Methods : Data were acquired on 70 isolated human lenses obtained from the Ramayamma International Eye-Bank, Hyderabad, India (age: newborn to 56 years, post-mortem time: 0.3 to 4.4 days). The lenses were placed in a combined Laser-Ray Tracing (LRT) and Optical Coherence Tomography (OCT) system (Ruggeri et al, Biomed Opt Exp, 2018). The LRT measures the slopes of on- and off-axis rays refracted through the lens. OCT images are used to reconstruct the 3D lens shape (Martinez-Enriquez et al, IOVS, 2020). Slopes of 49 rays from a 3 mm x 3 mm raster scan with 0.5 mm spacing were used to find the focus position (axial position that minimizes RMS spot size relative to centroid) for incidence angles ranging from -30° to +30° in 5° increment. The curvature of the measured image field was calculated from the variation of the focus position with the incidence angle. In addition, the radii of curvature of the tangential, sagittal, least confusion and Petzval surfaces were calculated from a model of the lens reconstructed using the lens anterior and posterior radii of curvature, thickness and calculated equivalent refractive index. The age-dependence of the field curvature obtained from the measurements and from the lens model constructed form the OCT images was quantified.

Results : The measured image field and calculated Petzval surface of the lens are concave and progressively flatten with age (shift towards less myopic peripheral defocus) (Figure 1). The measured field curvature is steeper than the curvature predicted using a uniform equivalent index, suggesting that the lens gradient contributes to field curvature.

Conclusions : Lens growth produces changes in the retinal image field curvature, which contribute to age-dependent changes in ocular peripheral defocus that may be a factor in refractive development.

This is a 2021 ARVO Annual Meeting abstract.

 

Figure 1: Age-dependence of the radius of curvature of the crystalline lens image fields.

Figure 1: Age-dependence of the radius of curvature of the crystalline lens image fields.

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