June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
In-vivo posterior retinal fibrillary structure visualized under triple input PS-OCT on a non-human primate
Author Affiliations & Notes
  • Xinyu Liu
    Singapore Eye Research Institute, Singapore, Singapore
    SERI-NTU Advanced Ocular Engineering (STANCE), Singapore
  • Mengyuan Ke
    Singapore Eye Research Institute, Singapore, Singapore
  • Liqin Jiang
    Singapore Eye Research Institute, Singapore, Singapore
  • Arumugam R Muralidharan
    Singapore Eye Research Institute, Singapore, Singapore
  • Raymond Najjar
    Singapore Eye Research Institute, Singapore, Singapore
    Duke-NUS Medical School, Singapore, Singapore
  • Martin Villiger
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, United States
  • Veluchamy A Barathi
    Singapore Eye Research Institute, Singapore, Singapore
    Duke-NUS Medical School, Singapore, Singapore
  • Leopold Schmetterer
    Singapore Eye Research Institute, Singapore, Singapore
    School of Chemical and Biomedical Engineering, Nanyang Technological University College of Engineering, Singapore, Singapore
  • Footnotes
    Commercial Relationships   Xinyu Liu, None; Mengyuan Ke, None; Liqin Jiang, None; Arumugam Muralidharan, None; Raymond Najjar, None; Martin Villiger, None; Veluchamy Barathi, None; Leopold Schmetterer, None
  • Footnotes
    Support  This research was supported by the Singapore Government through the Industry Alignment Fund - Industry Collaboration Project Grant (I1901E0038), and Johnson & Johnson Vision, A*STAR-Janssen World Without Disease 2017, National Institutes of Health P41EB-015903.
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 1923. doi:
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    • Get Citation

      Xinyu Liu, Mengyuan Ke, Liqin Jiang, Arumugam R Muralidharan, Raymond Najjar, Martin Villiger, Veluchamy A Barathi, Leopold Schmetterer; In-vivo posterior retinal fibrillary structure visualized under triple input PS-OCT on a non-human primate. Invest. Ophthalmol. Vis. Sci. 2021;62(8):1923.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : In the eye, fibrillary structures play vital roles for the eye functioning. Polarization sensitive optical coherence tomography (PS-OCT) is an in-vivo fibrillary tissue imaging tool. We developed a novel scheme of PS-OCT, named as triple input PS-OCT (TIPS-OCT), and investigated the fibrillary structures in the posterior eye of a non-human primate.

Methods : A Rhesus Macaque was anaesthetized and scanned using the proposed TIPS-OCT.

Results : In the peripapillary region of the sclera, we observed that a thin layer of radial fiber structure was distributed from the inner side and transited to thicker, multi-directional, interweaving circumferential fiber structure. The transition boundary can be clearly seen around the ONH.
In the macular region, we observed that the sclera was significantly thicker and primarily contained two orthogonally interweaving fibrillary structure. Fibrils from different directions were observed to entangle under the fovea spot, probably thickening and strengthening the sclera around the macular region.

Conclusions : TIPS-OCT provides new insight to understand the retinal fibrillary structure in vivo.

This is a 2021 ARVO Annual Meeting abstract.

 

Figure 1. (a) Enface projection of fibrillary distribution of RNFL. (b) A presentative cross-sectional intensity image. (c) Corresponding fibrillary structure image. (d-g) Sclera fibrillary structure from inner to outer layers. Insets, locations where sclera show rich and complex fibrillar distribution.

Figure 1. (a) Enface projection of fibrillary distribution of RNFL. (b) A presentative cross-sectional intensity image. (c) Corresponding fibrillary structure image. (d-g) Sclera fibrillary structure from inner to outer layers. Insets, locations where sclera show rich and complex fibrillar distribution.

 

Figure 2. (a) A presentative cross-sectional intensity image. (b) Corresponding fibrillary structure image. (c) Enface structure of Henle’s fiber layer around the fovea. (d-e) Sclera fibrillary structure from inner to outer side. (f) A representative H&E histology image of monkey retina. Insets, the layer where HFL is observed. White arrows: location of HFL.

Figure 2. (a) A presentative cross-sectional intensity image. (b) Corresponding fibrillary structure image. (c) Enface structure of Henle’s fiber layer around the fovea. (d-e) Sclera fibrillary structure from inner to outer side. (f) A representative H&E histology image of monkey retina. Insets, the layer where HFL is observed. White arrows: location of HFL.

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