June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Compensation of anatomical confounders improves the diagnostic ability of retinal nerve fiber layer thickness to detect glaucoma
Author Affiliations & Notes
  • Leopold Schmetterer
    Singapore Eye Research Institute, Singapore, Singapore
    Nanyang Technological University, Singapore, Singapore, Singapore
  • Florian Schwarzhans
    Medizinische Universitat Wien, Wien, Wien, Austria
  • Damon Wong
    Nanyang Technological University, Singapore, Singapore, Singapore
    Singapore Eye Research Institute, Singapore, Singapore
  • Ching-Yu Cheng
    Singapore Eye Research Institute, Singapore, Singapore
    Duke-NUS Medical School, Singapore, Singapore
  • Tin Aung
    Singapore Eye Research Institute, Singapore, Singapore
    Duke-NUS Medical School, Singapore, Singapore
  • Georg Fischer
    Medizinische Universitat Wien, Wien, Wien, Austria
  • Clemens Vass
    Medizinische Universitat Wien, Wien, Wien, Austria
  • Jacqueline Chua
    Singapore Eye Research Institute, Singapore, Singapore
    Duke-NUS Medical School, Singapore, Singapore
  • Footnotes
    Commercial Relationships   Leopold Schmetterer, None; Florian Schwarzhans, None; Damon Wong, None; Ching-Yu Cheng, None; Tin Aung, None; Georg Fischer, None; Clemens Vass, None; Jacqueline Chua, None
  • Footnotes
    Support  National Medical Research Council (CG/C010A/2017)
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 1860. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Leopold Schmetterer, Florian Schwarzhans, Damon Wong, Ching-Yu Cheng, Tin Aung, Georg Fischer, Clemens Vass, Jacqueline Chua; Compensation of anatomical confounders improves the diagnostic ability of retinal nerve fiber layer thickness to detect glaucoma. Invest. Ophthalmol. Vis. Sci. 2021;62(8):1860.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To determine the diagnostic ability of retinal nerve fiber layer (RNFL) thickness to detect glaucoma after compensating the RNFL thickness for demographic and anatomical factors.

Methods : This case-control study enrolled 2699 healthy participants, including Chinese, Indians and Malays to construct an Asian-specific compensation model, which was then tested in 738 eyes without glaucoma and 386 eyes with glaucoma (early, n = 231; moderate, n = 90; and, advanced, n = 65).Participants underwent Cirrus spectral-domain optical coherence tomography (SD-OCT; Carl Zeiss Meditec) imaging of the optic disc and macular cubes. Compensated RNFL thickness was generated based on ethnicity, age, refractive error, optic disc (ratio, orientation and area), fovea (distance and angle), and retinal vessel density. RNFL thickness measurements and their corresponding areas under the receiver operating characteristic curves (AUCs) were obtained.

Results : After applying the Asian-specific compensation model, the standard deviation (SD) of RNFL thickness reduced, where the effect was greatest for Chinese (16.8%), followed by Malays (13.4%) and then Indians (11.7%). Compensated RNFL outperformed measured RNFL for discrimination of early glaucoma (AUC = 0.89 vs 0.85; P<0.001), moderate glaucoma (AUC = 0.94 vs 0.91; P<0.001) and advanced glaucoma (AUC=0.98 vs 0.96; P<0.001).

Conclusions : Compensated RNFL showed better glaucoma discrimination capability than measured RNFL thickness in a multi-ethnic Asian group. This finding suggests there may be utility in accounting for demographic and anatomical variance in RNFL thickness to improve glaucoma detection.

This is a 2021 ARVO Annual Meeting abstract.

 

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×