June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Functional and Psychosocial Impact of Eye Disease in Pediatric Ebola Survivors, Sierra Leone
Author Affiliations & Notes
  • Dominick Canady
    Morehouse School of Medicine, Atlanta, Georgia, United States
  • Caleb Hartley
    Rollins School of Public Health, Emory University, Atlanta, Georgia, United States
  • Amy Cassedy
    Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States
  • Chris Miller
    Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
  • Sheila T Angeles-Han
    Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States
  • Matthew Jusu Vandy
    Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
  • Gilberte Bastien
    Morehouse School of Medicine, Atlanta, Georgia, United States
  • Natalie Weil
    Emory Eye Center, Emory University School of Medicine, Atlanta, Georgia, United States
  • Steven Yeh
    Emory Eye Center, Emory University School of Medicine, Atlanta, Georgia, United States
  • Jessica Shantha
    Emory Eye Center, Emory University School of Medicine, Atlanta, Georgia, United States
  • Footnotes
    Commercial Relationships   Dominick Canady, None; Caleb Hartley, None; Amy Cassedy, None; Chris Miller, None; Sheila Angeles-Han, None; Matthew Vandy, None; Gilberte Bastien, None; Natalie Weil, None; Steven Yeh, Emory Global Health Institute Marcus Foundation Combating Childhood Illness Seed Grant (F), K23 EY030158 (R), R01 EY029594 (R); Jessica Shantha, None
  • Footnotes
    Support  R01 EY029594 K23 EY030158 Emory Global Health Institute Marcus Foundation Combating Childhood Illness Seed Grant
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 1428. doi:
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      Dominick Canady, Caleb Hartley, Amy Cassedy, Chris Miller, Sheila T Angeles-Han, Matthew Jusu Vandy, Gilberte Bastien, Natalie Weil, Steven Yeh, Jessica Shantha; Functional and Psychosocial Impact of Eye Disease in Pediatric Ebola Survivors, Sierra Leone. Invest. Ophthalmol. Vis. Sci. 2021;62(8):1428.

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Abstract

Purpose : To determine the ophthalmic complications in pediatric Ebola virus disease (EVD) survivors and EVD close-contacts, and the impact on quality of life and mental health within Sierra Leone.

Methods : Cross-sectional study. Pediatric EVD survivors and first-degree close contact controls were identified through the Sierra Leone Association of Ebola Survivors and Ministry of Health. EVD survivor status was confirmed by Ebola serum IgG testing. Patients enrolled in this study underwent a medical questionnaire and, ocular examination, and Quality of Life was evaluated with the Pediatric Quality of Life Inventory Version 4.0 (PedsQL). PedsQL assessed holistic quality of life over 4 domains. 1) Physical Functioning 2) Emotional Functioning 3) Social Functioning 4) School function.

Results : A total of 86 Ebola affected pediatric patients were examined which included twenty-three EVD survivors and 63 close contacts. Of EVD survivors, 39.1% were female and mean age was 11.5 years. Among close contacts, 46% were female and mean age was 9.5 years. Higher prevalence of uveitis was observed in the EVD survivor (13.0%) cohort compared to close contacts (1.7%) (p=0.032). Overall, 56.5% and 42.9% of EVD survivor eyes and close contact eyes presented with an ocular diagnosis that impaired vision, there was no statistically significant difference. The PedsQL total score showed low overall quality life in both patient populations (60.6 vs 67.0, p=0.250). The emotional functioning domain parent report was significantly lower among parents of EVD survivors compared to close contacts (57.4 vs 70.0, p=0.035). The main driver was a greater number of parents of EVD survivors affirming the question: “I feel Sad or Blue” (48.21 vs 65.71, p=0.035)

Conclusions : We observed a high burden of ocular and psychosocial sequelae in pediatric Ebola survivors in Sierra Leone. While uveitis was observed with a higher prevalence in this cohort of pediatric EVD survivors, non-uveitis eye disease also led to substantial visual acuity impairment in both groups. Psychosocial health burden was also observed within this pediatric population, irrespective of EVD infection. Future studies that examine the relationship between eye health and mental health in pediatric EVD survivors could better define these important relationships, particularly given the current pandemic.

This is a 2021 ARVO Annual Meeting abstract.

 

 

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