June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Outcomes of using topical K2-EDTA as a chelating agent for treatment of band keratopathy in a tertiary hospital in the UK.
Author Affiliations & Notes
  • Cristian Cartes
    Ophthalmology, Royal Victoria Infirmary, Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
  • Sayali Pradhan
    Ophthalmology, Royal Victoria Infirmary, Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
  • Emma Spowart
    Ophthalmology, Royal Victoria Infirmary, Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
  • Francisco C Figueiredo
    Ophthalmology, Royal Victoria Infirmary, Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    Biosciences Institute, Newcastle University Faculty of Medical Sciences, Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
  • Footnotes
    Commercial Relationships   Cristian Cartes, None; Sayali Pradhan, None; Emma Spowart, None; Francisco Figueiredo, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 1320. doi:
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      Cristian Cartes, Sayali Pradhan, Emma Spowart, Francisco C Figueiredo; Outcomes of using topical K2-EDTA as a chelating agent for treatment of band keratopathy in a tertiary hospital in the UK.. Invest. Ophthalmol. Vis. Sci. 2021;62(8):1320.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Superficial keratectomy with topical disodium ethylenediaminetetraacetic acid (Na2-EDTA) is an established treatment for band keratopathy (BK). Use of the dipotassium form (K2-EDTA) acquired from easily available blood collection vacutainer tubes as an alternative to the commercially available Na2-EDTA was only recently reported in 2018. We report our experience of using K2-EDTA to treat band keratopathy.

Methods : Retrospective case series of 20 eyes (19 patients) undergoing superficial keratectomy with K2-EDTA chelation from July 2018 to September 2019. Symptomatic BK patients with visual impairment or discomfort from ocular surface instability were included. 12.3% K2-EDTA solution was applied topically after superficial keratectomy and chelation was achieved. Followed by placing a bandage contact lens to facilitate epithelial healing/comfort. Outcomes measured were BCVA, resolution of symptoms, time to re-epithelialisation, recurrence, complications, and need for any further treatment.

Results : Mean age was 67.4 years (SD 19.2; range: 24 - 88) and 55% were Males. The indications for the procedure included discomfort 12 eyes (60%), impaired vision in 7 (35%) and improve cosmetic appearance in 1 (5%). The mean operation time was 22 minutes (SD 8) timed from application of the drape and including superficial keratectomy. Effective clearance of the BK was accomplished in all patients. No major complications reported. Post op BCVA improved in 4 but remained the same in 3 eyes undergoing the procedure for visual improvement due to associated corneal scarring (n=2) and age-related macular degeneration (n=1). Corneal surface healing was achieved in all patients except one who developed a persistent epithelial defect due to underlying neurotrophic cornea secondary to past acanthamoeba keratitis resolving with temporary lateral tarsorrhaphy. Recurrence of BSK was noted in none of the patients on mean 150 days (SD 121) follow up time.

Conclusions : Superficial keratectomy with topical 12.3 % K2-EDTA chelation serves as an efficient and safe surgical technique for band shaped keratopathy clearance and is cheaper as compared to the traditional Na2-EDTA solution.

This is a 2021 ARVO Annual Meeting abstract.

 

K2-EDTA performed in a patient for relieving discomfort; Pre-operative (A) and Post-operative (B).

K2-EDTA performed in a patient for relieving discomfort; Pre-operative (A) and Post-operative (B).

 



K2-EDTA performed in a patient for visual improvement; Pre-operative (A) and Post-operative (B).



K2-EDTA performed in a patient for visual improvement; Pre-operative (A) and Post-operative (B).

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