June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Correlation of AI-quantified retinal morphology with topographic function in neovascular AMD
Author Affiliations & Notes
  • Sophie Riedl
    Department of Ophthalmology, Medizinische Universitat Wien, Wien, Wien, Austria
  • Markus Schranz
    Department of Ophthalmology, Medizinische Universitat Wien, Wien, Wien, Austria
  • Oliver Leingang
    Department of Ophthalmology, Medizinische Universitat Wien, Wien, Wien, Austria
  • Gregor Sebastian Reiter
    Department of Ophthalmology, Medizinische Universitat Wien, Wien, Wien, Austria
  • Christoph Grechenig
    Department of Ophthalmology, Medizinische Universitat Wien, Wien, Wien, Austria
  • Wolf-Dieter Vogl
    Department of Ophthalmology, Medizinische Universitat Wien, Wien, Wien, Austria
  • Mustafa Arikan
    Department of Ophthalmology, Medizinische Universitat Wien, Wien, Wien, Austria
  • Philipp Ken Roberts
    Department of Ophthalmology, Medizinische Universitat Wien, Wien, Wien, Austria
  • Irene Steiner
    Center for Medical Statistics, Informatics and Intelligent Systems, Section for Medical Statistics, Medizinische Universitat Wien, Wien, Wien, Austria
  • Hrvoje Bogunovic
    Department of Ophthalmology, Medizinische Universitat Wien, Wien, Wien, Austria
  • Ursula Schmidt-Erfurth
    Department of Ophthalmology, Medizinische Universitat Wien, Wien, Wien, Austria
  • Footnotes
    Commercial Relationships   Sophie Riedl, None; Markus Schranz, None; Oliver Leingang, None; Gregor Reiter, None; Christoph Grechenig, None; Wolf-Dieter Vogl, None; Mustafa Arikan, None; Philipp Roberts, None; Irene Steiner, None; Hrvoje Bogunovic, None; Ursula Schmidt-Erfurth, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 105. doi:
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      Sophie Riedl, Markus Schranz, Oliver Leingang, Gregor Sebastian Reiter, Christoph Grechenig, Wolf-Dieter Vogl, Mustafa Arikan, Philipp Ken Roberts, Irene Steiner, Hrvoje Bogunovic, Ursula Schmidt-Erfurth; Correlation of AI-quantified retinal morphology with topographic function in neovascular AMD. Invest. Ophthalmol. Vis. Sci. 2021;62(8):105.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To establish precise topographic structure-function relation in neovascular age-related macular degeneration (nAMD) by correlating AI-quantified fluid and photoreceptor (PR) alteration with retinal sensitivity (RS) as assessed by microperimetry (MP).

Methods : Morphology and function of n=38 eyes of 38 consecutive patients with nAMD were analyzed at the treatment-naïve stage and one month following an aflibercept loading dose. SD-OCT data was acquired using Spectralis OCT. Intraretinal fluid (IRF), subretinal fluid (SRF) and PR volumes were quantified using fully automated segmentations based on deep learning. RS was measured using a fovea-centered grid of 45 locations on the Nidek MP-3. Locations were registered to OCT volumes to precisely assess co-located morphology, which we report as nanoliters (nl) within a cuboid volume corresponding to MP-locations (Figure 1). Mixed models were computed to analyze the effect of IRF, SRF and PR volumes on RS at the corresponding location.

Results : RS and morphology at MP-locations are summarized in Table 1. Results of mixed models are reported per nl of fluid/PR. At baseline RS increased with PR volume (fovea: +5.73 dB; parafovea: +6.13 dB; perifovea: +2.95 dB, all p<0.001). IRF corresponded to decreased RS by -1.51 dB (p<0.001) and -1.13 dB (p=0.002) in the fovea and parafovea. For SRF, a decrease in RS by -1.88 dB (p<0.001) and -2.15 dB (p<0.001) was revealed in the para- and perifovea. By month 3 the positive association of RS with PR was even stronger in the fovea, parafovea and perifovea (+11,34 dB; +8.94 dB; +8.32 dB, all p<0.001). A significant effect of fluid remained for IRF in the parafovea (-7.86 dB, p=0.023) and SRF in the fovea (-1.65 dB, p=0.012). Reduction of foveal fluid expectedly corresponded to significantly increased RS by +0.59 dB (p=0.011) for IRF and +0.53 dB (p=0.028) for SRF. Furthermore, reduction of parafoveal SRF resulted in a RS gain of +0.82 dB (p=0.012). Interestingly, increase in PR corresponded to increased RS in the fovea (+1.88 dB, p=0.003), but decreased RS in the para- and perifovea (-1.61 dB and -2.01 dB, p=0.022 and p=0.008).

Conclusions : PR integrity is essential for topographic function. Resolution of foveal fluid and SRF in the parafovea corresponds to RS gains. In summary, retinal morphology, assessed by automated methods, shows meaningful correspondence with precise topographically corresponding RS.

This is a 2021 ARVO Annual Meeting abstract.

 

 

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