Comparison of Heru Visual field as a cloud based artificial intelligence-powered software application downloadable on commercial augmented reality headset with Humphrey Field Analyzer SITA Standard

Abstract

Purpose : 1-To evaluate the comparability of visual field (VF) measurements obtained using Heru VF that uses a cloud based artificial intelligence (AI)-powered software application downloadable on commercial augmented reality headset to those of standard automated perimetry in normal, glaucoma and neuro-ophthalmology patients.
2-To evaluate the reproducibility of Heru VF measurements in normal and pathological eyes.

Methods : This prospective clinical study included 47 eyes (21 healthy and 26 of patients with glaucoma and neuro-ophthalmic diseases). VF results were obtained using Heru VF application that uses a cloud based AI testing algorithm (Heru Visual Field, Miami) downloaded on Magic Leap 1 augmented reality device (Magic Leap, Plantation, FL) and a Humphrey Field Analyzer (HFA) 800 series (Carl Zeiss Meditec, Inc, Dublin, CA, USA) using SITA Standard. Patients underwent 24-2 test point pattern in both devices. Comparing test times and correlations of threshold values (TV) and mean deviations (MD) obtained using both were calculated to determine agreement. Test time (TT) was compared between the two devices. In Heru device, testing is paused when patient is not fixating, thus testing time excludes idle time when patient was not interacting with the test. Pathological VF defects seen were typical glaucomatous VF defects and ring scotomas.

Results : There were strong correlations between Heru VF MD and TV and those of HFA in normal, glaucoma and neuro-ophthalmology patients (R=0.91, P<0.001 and R=0.81, P<0.001, respectively). MD and TV of Heru VF in normal and pathologic eyes showed excellent reproducibility with ICC of 0.95 (95%CI 0.86-0.98) and 0.80 (95%CI 0.78-0.82), respectively. Heru VF was statistically significantly faster than the HFA SITA Standard (4.3 vs 5 minutes respectively; P<0.001). Mean TT in Heru VF was 15.4% faster than HFA in pathologic eyes (4.7 vs 5.5 minutes, P<0.001) and 7.8% faster than HFA in healthy eyes (3.9 vs 4.24 minutes, P<0.001).

Conclusions : Central VF measurements from Heru VF that uses a cloud-based AI-powered software application downloadable on commercial augmented reality headset were comparable to HFA in normal, glaucoma and neuro-ophthalmology patients. Heru VF measurements are reproducible in normal and pathologic patients. Heru VF is faster than HFA SITA Standard.

This is a 2021 ARVO Annual Meeting abstract.