June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Characteristics Associated with Proliferative Sickle Cell Retinopathy
Author Affiliations & Notes
  • Nathaniel Jackson
    Yeshiva University Albert Einstein College of Medicine, Bronx, New York, United States
  • Rakin Muhtadi
    Yeshiva University Albert Einstein College of Medicine, Bronx, New York, United States
  • Ashley Radparvar
    Yeshiva University Albert Einstein College of Medicine, Bronx, New York, United States
  • James Lin
    Ophthalmology & Visual Sciences, Montefiore Medical Center, Bronx, New York, United States
    Yeshiva University Albert Einstein College of Medicine, Bronx, New York, United States
  • Umar Mian
    Ophthalmology & Visual Sciences, Montefiore Medical Center, Bronx, New York, United States
    Yeshiva University Albert Einstein College of Medicine, Bronx, New York, United States
  • Footnotes
    Commercial Relationships   Nathaniel Jackson, None; Rakin Muhtadi, None; Ashley Radparvar, None; James Lin, None; Umar Mian, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 3193. doi:
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    • Get Citation

      Nathaniel Jackson, Rakin Muhtadi, Ashley Radparvar, James Lin, Umar Mian; Characteristics Associated with Proliferative Sickle Cell Retinopathy. Invest. Ophthalmol. Vis. Sci. 2021;62(8):3193.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Blinding retinopathy in sickle cell disease is usually associated with vitreous hemorrhage or tractional retinal detachment, which are preceded by neovascularization (NVE) of the retina. There is currently no widely accepted framework for predicting progression to proliferative sickle retinopathy (PSR). We evaluated serial fluorescein angiograms (FA) to identify variables associated with PSR in this descriptive retrospective qualitative study.

Methods : Serial FA’s of 7 patients with sickle cell disease (4/7 SC, 1/7 SS, 1/7 SB, 1/7 S-O Arab) with progression of retinopathy to PSR were reviewed. All patients were seen at Montefiore Medical Center in Bronx, New York. Progression was defined as new NVE or increase in size or fluorescence of persistent NVE. FA were reviewed by 3 medical students trained by 2 retina specialists. Agreement on variables was obtained at time of grading. Variables included distance of retina visualized, capillary dropout (CD), arteriovenous loops at vascular border (AV Loop), arborization with and without staining, and CD posterior to vascular border (CDPB). Variables were evaluated by clock hour ±0.5 centered on the temporal ON. Clock hours without visible border due to hemorrhage, blurred image, or lack of image were excluded from analysis. Distance of variables from temporal ON was calculated with unit of distance, X, equal to the distance between temporal optic disc and fovea. Student's T-test and chi-square test of independence were used to analyze the data.

Results : 288 total clock hours were analyzed, 163 contained visualizable border, and 18 contained NVE. CDPB and arborization with and without staining were significantly more common in clock hours with NVE. There was also significantly less distance captured in the images of clock hours with NVE. CD and AV loops trended towards being more common in clock hours with NVE.

Conclusions : It is important to perform routine serial FA’s in patients with sickle cell disease to better evaluate the risk of developing NVE. Patients who have FA’s with CDPB and/or arborization should be followed more closely as these characteristics may indicate a higher chance of developing proliferative disease.

This is a 2021 ARVO Annual Meeting abstract.

 

Variables for clock hours with neovascularization vs. clock hours without neovascularization

Variables for clock hours with neovascularization vs. clock hours without neovascularization

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