June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Inter-Individual Variability of the Scleral and Ciliary Muscle Optical Attenuation and its Implication for Transscleral Laser Therapy
Author Affiliations & Notes
  • Gabrielle Monterano Mesquita
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida, United States
  • Disha Patel
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida, United States
  • Yu-Cherng Chang
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida, United States
  • Florence Cabot
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Anne Bates Leach Eye Hospital, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Marco Ruggeri
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida, United States
  • sonia h yoo
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Anne Bates Leach Eye Hospital, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Jean-Marie A Parel
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Brien Holden Vision Institute Limited, Sydney, New South Wales, Australia
  • Arthur Ho
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Brien Holden Vision Institute Limited, Sydney, New South Wales, Australia
  • Fabrice Manns
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida, United States
  • Footnotes
    Commercial Relationships   Gabrielle Monterano Mesquita, None; Disha Patel, None; Yu-Cherng Chang, None; Florence Cabot, None; Marco Ruggeri, None; sonia yoo, None; Jean-Marie Parel, None; Arthur Ho, None; Fabrice Manns, None
  • Footnotes
    Support  National Eye Institute Grants 2R01EY14225, P30EY14801 (Center Grant), 1F30EY027162; the Florida Lions Eye Bank and the Beauty of Sight Foundation; Research to Prevent Blindness; the Henri and Flore Lesieur Foundation (JMP); donations from Drs. HW, Flynn, KR Olsen and ME Hildebrandt, Raksha Urs and Aaron Furtado.
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 2317. doi:
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      Gabrielle Monterano Mesquita, Disha Patel, Yu-Cherng Chang, Florence Cabot, Marco Ruggeri, sonia h yoo, Jean-Marie A Parel, Arthur Ho, Fabrice Manns; Inter-Individual Variability of the Scleral and Ciliary Muscle Optical Attenuation and its Implication for Transscleral Laser Therapy. Invest. Ophthalmol. Vis. Sci. 2021;62(8):2317.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Inter-individual variations in the optical properties of the sclera and ciliary body may be a factor in the variability of treatment outcomes of transscleral and transpupillary laser therapies, such as cyclophotocoagulation. The goal of this study is to quantify inter-individual variations of the attenuation of the sclera and ciliary muscle with OCT.

Methods : The sclera and ciliary body of the left eye of 41 healthy subjects (age range: 16 to 60 years) were imaged using a commercial spectral domain OCT system following an IRB-approved protocol (λc = 1325 nm, Telesto I, Thorlabs, NJ). Rectangular regions of interest (ROI) consisting of 100 A-lines (width = 0.35mm) were identified in the sclera from the episcleral - sclera to the sclera - ciliary muscle boundary (depth: 0.43 ± 0.06 mm) and in the ciliary muscle from the sclera - ciliary muscle boundary to the muscle inner boundary (depth: 0.29 ± 0.07 mm). The attenuation coefficient (AC) along each A-line of the ROI was calculated from an exponential fit of the axial intensity profile (Fig 1). A-lines with ACs that were outside 2 standard deviations from the mean were discarded. This step was repeated and the truncated mean and standard deviation of the AC within the ROI, with outliers removed was calculated.

Results : The ACs of the sclera and ciliary muscle ranged from 1.38 to 4.55 mm-1 and 1.88 to 5.00 mm-1 (mean: 3.26 ± 0.95 mm-1 and 3.74 ± 0.76 mm-1), respectively (Fig 2).

Conclusions : There is a large inter-individual variation of the scleral and ciliary muscle attenuation which produces significant variations in the energy reaching the ciliary body. The results suggest that a personalized laser treatment that takes into account scleral attenuation might improve treatment outcomes across individuals.

This is a 2021 ARVO Annual Meeting abstract.

 

Data analysis of a 17 y/o subject. A and C) OCT images of the ROI for the sclera and ciliary muscle. B and D) ACs measured from all 100 A-lines. The mean and 2 times the standard deviation (blue lines) of the 100 A-lines, and the mean and 2 times the standard deviation (red lines) of the points within the blue lines. The scleral and ciliary muscle ACs for this subject were 4.54 mm-1 and 3.32 mm-1, respectively.

Data analysis of a 17 y/o subject. A and C) OCT images of the ROI for the sclera and ciliary muscle. B and D) ACs measured from all 100 A-lines. The mean and 2 times the standard deviation (blue lines) of the 100 A-lines, and the mean and 2 times the standard deviation (red lines) of the points within the blue lines. The scleral and ciliary muscle ACs for this subject were 4.54 mm-1 and 3.32 mm-1, respectively.

 

Distribution of the scleral and ciliary muscle AC.

Distribution of the scleral and ciliary muscle AC.

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