June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Pore Shape Variation in Glaucomatous Lamina Cribrosa
Author Affiliations & Notes
  • Behnam Tayebi
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
    Tech4Health and Neuroscience Institutes, NYU Langone Health, New York, New York, United States
  • Zeinab Ghassabi
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
  • Joel S Schuman
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
    Departments of Biomedical Engineering and Electrical & Computer Engineering, New York University, New York, New York, United States
  • Palaiologos Alexopoulos
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
  • Mengfei Wu
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
    Departments of Population Health and Environmental Medicine, NYU Langone Health, New York, New York, United States
  • Ronald Zambrano
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
  • Hiroshi Ishikawa
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
    Departments of Biomedical Engineering and Electrical & Computer Engineering, New York University, New York, New York, United States
  • Gadi Wollstein
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
    Departments of Biomedical Engineering and Electrical & Computer Engineering, New York University, New York, New York, United States
  • Footnotes
    Commercial Relationships   Behnam Tayebi, None; Zeinab Ghassabi, None; Joel Schuman, Ziess (P); Palaiologos Alexopoulos, None; Mengfei Wu, None; Ronald Zambrano, None; Hiroshi Ishikawa, None; Gadi Wollstein, None
  • Footnotes
    Support  NIH R01 EY013178; P30 EY013079
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 1847. doi:
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    • Get Citation

      Behnam Tayebi, Zeinab Ghassabi, Joel S Schuman, Palaiologos Alexopoulos, Mengfei Wu, Ronald Zambrano, Hiroshi Ishikawa, Gadi Wollstein; Pore Shape Variation in Glaucomatous Lamina Cribrosa. Invest. Ophthalmol. Vis. Sci. 2021;62(8):1847.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The lamina cribrosa (LC) is considered to play an important role in the pathogenesis of glaucoma. In this study, we investigate the shape variation (SV) of the LC pores as a potential biomarker for quantifying the morphological irregularity in vivo.

Methods : 36 healthy and 14 glaucomatous (GL) eyes (total: 39 subjects) underwent a comprehensive ophthalmic examination and scanning of the optic nerve head with swept-source OCT (Table 1). Images were converted to isotropic and pores were segmented using ImageJ. SV was defined as the mean-squared error of the pore pattern with respect to a solid circle (Figure 1(a)) with SV of a circle marked as zero, and higher SV value with increasing shape irregularity. SV of each pore was automatically calculated by a MATLAB code. The overall SV value was generated as the average of SV in the stack of individual slices. Age effect on SV was examined in all healthy eyes and a subset of 14 eyes was selected for age-matched comparison with the glaucomatous eyes (Table 1).

Results : No significant correlation was detected between SV and age (p=0.145; Spearman correlation) in all healthy subjects. Examining the effect of depth on the difference between SV of glaucomatous and healthy eyes, the posterior third of the LC had significantly lower than other sections (p=0.007; Figure 1(b)). SV in glaucoma eyes was significantly higher than in the healthy group (p=0.008; Figure 1(c)).

Conclusions : We demonstrated morphological differences in pore shape variation between healthy and glaucoma eyes that is mostly affecting the anterior 2/3 of the LC. Further studies are warranted to assess the use of SV as a structural biomarker in glaucoma.

This is a 2021 ARVO Annual Meeting abstract.

 

Fig. 1. (a) Shape variation. Shape variation changes by (b) LC depth (36 eyes) and (c) diagnosis (14 eyes).

Fig. 1. (a) Shape variation. Shape variation changes by (b) LC depth (36 eyes) and (c) diagnosis (14 eyes).

 

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