Abstract
Purpose :
To evaluate tear film surface quality (TFSQ) over 12 months of soft daily disposable contact lens (CL) wear using non-invasive method.
Methods :
Fifty healthy subjects aged (mean ± standard deviation) 25.7 ± 4.3 years were prescribed with silicone hydrogel (SiHy) or hydrogel (Hy). The protocol consisted of baseline visit including first(F)/mean(M) non-invasive keratometry break-up times (F/MNIKBUT, K5M, Oculus Optikgeräte GmbH, Wetzlar, Germany), fluorescein tear film break-up time (FBUT), and corneal and conjunctival staining. At the end of the fitting day (day 2), the preferred lens was chosen based on objective measurements of contact lens fit, reported subjective comfort after four hours of wear and pre-lens TFSQ measurements. Thereafter, visits occurred at 2 weeks (CL check) and at 3, 6, and 12 months. TFSQ was measured over this period and differences between SiHy (n = 34) and Hy (n=16) fitted group were assessed.
Results :
FNIKBUT showed statistically significant differences between baseline (pre-fitting) and other visits: (P< 0.001 for Day 2 and at 3, 6, and 12-month visit, P < 0.001 for Day 2 and at 3, 6, and 12-month visit, respectively) and in MNIKBUT between baseline (pre-fitting) and other visits (P=0.004, P<0.001, P<0.001, P<0.001 for Day 2 and at 3, 6, and 12-month visit, respectively). Across all visits, there were no significant differences in the measurements associated with both lens types for FBUT, corneal staining, conjunctival staining, FNIKBUT, and MNIKBUT. Measurements with F/M NIKBUT were found to be the same and stable from Day 2, which indicates that TFSQ can be assessed and monitored reliably with NIKBUT.
Conclusions :
Throughout the course of the study, TFSQ was unaffected during CL wear and NIKBUT showed to be the same after a four-hour and 12-month period. Therefore, NIKBUT can be a promising indicator to evaluate TFSQ and furthermore improving CL wear success rate.
This is a 2021 ARVO Annual Meeting abstract.