June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Pilot study: Examining relationship among CLDEQ-8 defined classes, blink intervals, and tear film metrics
Author Affiliations & Notes
  • Greg Hofmann
    Johnson and Johnson Vision Care Inc, Jacksonville, Florida, United States
  • Vrushali Korde
    Johnson and Johnson Vision Care Inc, Jacksonville, Florida, United States
  • Nicole Franklin
    Johnson and Johnson Vision Care Inc, Jacksonville, Florida, United States
  • Patricia Martin
    Johnson and Johnson Vision Care Inc, Jacksonville, Florida, United States
  • Jie Xu
    Johnson and Johnson Vision Care Inc, Jacksonville, Florida, United States
  • John R. Buch
    Johnson and Johnson Vision Care Inc, Jacksonville, Florida, United States
  • Andrej Fogelton
    Blinkingmatters.com, Trenčín, Slovakia
  • Footnotes
    Commercial Relationships   Greg Hofmann, Johnson and Johnson Vision Care (E); Vrushali Korde, Johnson and Johnson vision care (E); Nicole Franklin, Johnson and Johnson Vision Care (E); Patricia Martin, Johnson and Johnson vison care (E); Jie Xu, Johnson and Johnson Vision Care (E); John Buch, Johnson and Johnson Vision Care (E); Andrej Fogelton, blinkingmatters.com (E)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 671. doi:
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      Greg Hofmann, Vrushali Korde, Nicole Franklin, Patricia Martin, Jie Xu, John R. Buch, Andrej Fogelton; Pilot study: Examining relationship among CLDEQ-8 defined classes, blink intervals, and tear film metrics. Invest. Ophthalmol. Vis. Sci. 2021;62(8):671.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the association between CLDEQ-8 classes, blink frequency during digital device use, tear film metrics, and a metric that emphasizes blinks that occur after the tear film has destabilized.

Methods : A bilateral, dispensing, randomized, double-masked 2x2 cross over study with a 2-week washout was executed. Two silicone hydrogel investigational soft contact lenses were employed, differing only by hydration method. The study included 6 visits: a baseline evaluation and lens fitting, a 1-week follow-up (FU) after 8 hours of lens wear, and a 2-week FU after 8 hours of lens wear. After a 2-week washout with habitual contact lens wear, this was repeated using the second investigational lens. A total of 37 subjects completed the study. At both 1-week FUs, 2 measures of tear stability were evaluated using the Oculus Keratograph 5M and a customized dynamic iDesign wavefront system, and the interblink interval (IBI) was measured while the subject watched a 5-minute video on a tablet. During this measurement, a video of each subject was recorded and analyzed using custom software to yield the IBIs. Contact Lens Dry Eye Questionnaire-8 (CLDEQ-8) was also administered at these 1-week FUs, however this questionnaire is not validated at the 1-week wear timepoint. Classes were defined using CLDEQ-8 scores, as follows. Poor and fair ≥ 15; 7 < good and very good < 15; excellent subjects ≤ 7.
Descriptive statistics, by class, were calculated for the IBI, NIKBUT, wavefront RMS, and ocular protection index (OPI) calculated using the NIKBUT and IBI.

Results : Mean or median IBI and mean NIKBUT, plotted by class, did not point to a relationship between the metrics and classes. Plots of the wavefront RMS suggested an increase of RMS and plots of the OPI suggested a decrease in OPI with increasing symptom class.

Conclusions : Combining the NIKBUT tear stability and IBI (OPI metric) appeared to provide better agreement with symptom classes defined by CLDEQ-8 as compared to using IBI or NIKBUT alone. Further investigation of dryness symptoms and discomfort during digital device use, and the interaction between the blink frequency and tear film metrics are warranted.

This is a 2021 ARVO Annual Meeting abstract.

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