Choroidal thickness distribution among different types of CSCR based on multimodal-imaging based classification

Abstract

Purpose : We recently reported a multimodal, imaging-based classification classifying Central Serous Chorioretinopathy (CSCR) into simple and complex types depending upon the extent of the disease. In this retrospective, multi-center, observational clinical study, we aimed to investigate subfoveal choroidal thickness (SFCT) among different types of CSCR and its predictive role for treatment outcomes for each subgroup.

Methods : 104 patients with CSCR underwent retrospective chart review focusing on date of initial presentation followed by 3, 6 and 12 month follow-up. Patients were classified into simple or complex CSCR based on a priori clinical criteria and then further classified into primary, recurrent or resolved depending on their clinical course. Various OCT parameters including SFCT, outer retinal atrophy, and central macular thickness (CMT) were evaluated at each visit by masked observers.

Results : Of all studied patients, average age was 52.7 ± 10.6 years with 66.7% being male. The odds ratio of developing recurrent CSCR versus primary CSCR between simple and complex initial presentations was 0.115 (95% CI 0.040-0.350). The mean initial CMT in simple primary was 446.19 ± 136.51 versus 360 ± 48.56 (p <0.05). The mean initial SFCT between simple CSCR and complex CSCR was 384.95 ± 97.48 and 419.05± 106.64 (p<0.10).

Conclusions : Preliminary data suggests that there is prognostic and diagnostic value in SFCT and CMT on initial presentation. The future implication for this project is to use clinically objective data to guide treatment as per a new multimodal classification. Further retrospective chart review is underway to increase statistical power and there is ongoing analysis to investigate the relationship between SFCT and CMT to treatment response.

This is a 2021 ARVO Annual Meeting abstract.