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Donato Colantuono, Eric H Souied, Francesca Amoroso, Vittorio Capuano, Giuseppe Querques, Alexandra Miere; Multimodal imaging and clinical characteristics of peripapillary choroidal neovascularization in age-related macular degeneration.. Invest. Ophthalmol. Vis. Sci. 2021;62(8):646.
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To analyze and describe the clinical and imaging characteristics of a series of patients with peripapillary choroidal neovascularization (PCN) in the context of age-related macular degeneration (AMD) and to investigate a possible relationship between PCN and the pachychoroid disease spectrum (PDS).
Case series of patients diagnosed with PCN in the Department of Ophthalmology of the Centre Hospitalier Intercommunal de Créteil between January 2000 and January 2018 were retrospectively included. Multimodal imaging, including OCTA (Plex Elite, Carl Zeiss Meditec, Inc., Dublin, CA) was obtained for all patients. Choroidal thickness (CT) was measured horizontally across the fovea and circumferentially around the temporal side of the disk to study its relationship to neovascularization. PCN morphology, area and vascular density were investigated in all cases.
Thirty-five eyes of 26 patients with PCN were included in this study, of which 32 eyes (91.4%) had a focal or diffuse increase in CT, 35/35 eyes had pachyvessels (100%), 10 eyes of 35 (28.6%) had choroidal vascular hyperpermeability and 34 eyes of 35 (97.1%) showed vessel attenuation of the inner choroid. Twelve out of 35 (34.2%) developped peripapillary aneurismal type 1 neovascularization colocalizing with the PCN during follow up. OCTA revealed a densly packed high flow network in the ORCC slab in all cases. The mean PCN area averaged 3.56 mm2 and the VD averaged 67.2%.
Analysis of choroidal structure, previously described in PDS, performed consistently when applied to our PCN series, thus supporting the hypothesis that PCN may be a distinct PDS variant.
This is a 2021 ARVO Annual Meeting abstract.
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