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Jose Ramirez, Inés López Cuenca, Elena Salobrar-García, Jose A. Fernández-Albarral, Pilar Rojas, Lorena Elvira-Hurtado, Juan J. Salazar, Ana Barabash, Ana Ramirez, Rosa de Hoz; Visual acuity and contrast sensitivity are slightly modified in young asymptomatic relatives of Alzheimer’s disease patients. Invest. Ophthalmol. Vis. Sci. 2021;62(8):615.
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© ARVO (1962-2015); The Authors (2016-present)
Alzheimer’s diseases is a neurodegenerative disease, whose signs can appear decades before clinically detectable symptoms. In addition to age, genetic factors are one of the most important risk factors. One population at increased risk are first-degree relatives of AD patients, at a 2- to 3-fold increased risk for developing dementia. This probability increases if relatives are carriers of the apolipoprotein E (APOE) ε4 allele.The aim of the present study was to analyze the possible changes that may occur in visual acuity (VA) and contrast sensitive test (CST) in in first-degree relatives of Alzheimer’s disease patients who are carriers of ε4 allele for the ApoE.
A complete eye examination was performed in all participants, who were free of ocular pathology. This case-control study was conducted in 28 subjects with family history of AD (FH+) , ApoE ε4 carriers and with a mean age of 53.39 years and 16 age-matched control subjects without a family history of AD (FH-), ApoE ε4 non-carriers and with a mean age of 53.94 years.
In comparison with FH- ApoE ε4 non-carriers, in FH+ ApoE ε4 carriers we found statistical significant increase (p<0.05) both inVA (1.04±0.10, FH+ vs 0.98±0.04, FH-) and in CS in the spatial frequency (SF) of 12cycles/degree (1.68±0.18, FH+ vs 1.54±0.17, FH-).
The VA and CST registered changes in FH+ ApoE ε4 carriers compared to FH- ApoE ε4 non-carriers. In first-degree relatives of AD patients, an increase of VA and CS in the 12cicles/degree SF could be the first functional changes to appear.
This is a 2021 ARVO Annual Meeting abstract.
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