Abstract
Purpose :
In-vitro evaluation of increased hydroxyl radical scavenging activity of a new dispersive ophthalmic viscosurgical device (ClearVisc OVD, Bausch and Lomb, Inc.).
Methods :
Using the 2-deoxy-D-ribose oxidation method, hydroxyl radicals (OH) are formed for detection via high-performance liquid chromatography (HPLC) with UV detection. Various OVD components such as buffer and additives as well as other OVD formulations have been utilized to measure their ability to scavenge free radicals that are typically formed during phacoemulsification.
Results :
The results of testing provide a comparison of water as control as well as standard sodium hyaluronate formulations to the ClearVisc OVD. The results show the effectiveness of the new buffer and sorbitol additive capabilities to scavenge free radicals.
Conclusions :
Hydroxyl free radicals generated during phacoemulsification in cataract surgery can contribute to corneal endothelial damage. The overall results in this study show the effectiveness of the combination of buffer and additives in this new dispersive OVD in hydroxyl free radical inhibition.
This is a 2021 ARVO Annual Meeting abstract.