June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Intraocular Pressure and Its Determinants in a Very Old Population. The Ural Very Old Study
Author Affiliations & Notes
  • Mukharram Bikbov
    Ufimskij naucno-issledovatel'skij institut glaznyh boleznej, Ufa, Bashkortostan, Russian Federation
  • Gyulli Kazakbaeva
    Ufimskij naucno-issledovatel'skij institut glaznyh boleznej, Ufa, Bashkortostan, Russian Federation
  • Songhomitra Panda-Jonas
    Institute of Clinical and Scientific Opthalmology and Acupuncture Jonas&Panda, Heidelberg, Germany
  • Ellina Rakhimova
    Ufimskij naucno-issledovatel'skij institut glaznyh boleznej, Ufa, Bashkortostan, Russian Federation
  • Jost Jonas
    Department of Opthalmology, Ruprecht Karls Universitat Heidelberg, Mannheim, Germany
  • Footnotes
    Commercial Relationships   Mukharram Bikbov, None; Gyulli Kazakbaeva, None; Songhomitra Panda-Jonas, None; Ellina Rakhimova, None; Jost Jonas, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 557. doi:
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      Mukharram Bikbov, Gyulli Kazakbaeva, Songhomitra Panda-Jonas, Ellina Rakhimova, Jost Jonas; Intraocular Pressure and Its Determinants in a Very Old Population. The Ural Very Old Study. Invest. Ophthalmol. Vis. Sci. 2021;62(8):557.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To assess the distribution of intraocular pressure (IOP) and its determinants in a very old population.

Methods : The population-based Ural Very Old Study (UVOS) was performed in a rural and urban region of Bashkortostan/Russia and consisted of 1526 (81.1%) out of 1882 eligible individuals aged 85+ years. As part of a series of medical and ophthalmological examinations, we measured IOP upon non-contact tonometry.

Results : The study included 1042 (68.3%) individuals with available IOP readings (mean age:88.1±2.7 years). Mean IOP was 14.6±5.3 mmHg (median:14 mmHg; range:6-60mmHg; 95%confidence interval (CI): 14.3,15.0) and 15.1±5.1mmHg (median:14mmHg; range:5-49mmHg; 95%CI: 14.8,15.4) in the right eyes and left eyes, respectively. In multivariable analysis, higher IOP was associated (regression coefficient r:0.35) with the systemic parameters of younger age (standardized regression coefficient beta:-0.08; non-standardized regression coefficient B:-0.13; 95%CI: -0.26, -0.01; P=0.04), female sex (beta:0.15; B:1.26; 95%CI:0.57,1.94; P=0.001) and higher systolic blood pressure (beta:0.18; B:0.03;95%CI:0.0.02,0.04; P<0.001), and the ocular parameters of thicker central corneal thickness (beta:0.18; B:0.02; 95%CI:0.01,0.03; P<0.001), longer axial length (beta:0.09; B:0.32;95%CI:0.05,0.60; P=0.02) and status after cataract surgery (beta:-0.13; B:-0.26; 95%CI:-1.59,-0.37;P=0.002). In that model, the IOP measurements increased by 0.19 mmHg (95%CI: 0.10,0.27) for each increase in central corneal thickness by 10 μm. In an univariate analysis, the IOP readings increased by 0.21 mmHg (95%CI: 0.13,0.29) for each increase in central corneal thickness by 10 μm.

Conclusions : In this population-based recruited study population aged 85+ years, IOP decreased with older age and increased with blood pressure and was higher in females. As in younger populations, the IOP readings were dependent on central corneal thickness, increased with longer axial length and were lower in eyes after cataract surgery.

This is a 2021 ARVO Annual Meeting abstract.

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