Abstract
Purpose :
To assess the distribution of intraocular pressure (IOP) and its determinants in a very old population.
Methods :
The population-based Ural Very Old Study (UVOS) was performed in a rural and urban region of Bashkortostan/Russia and consisted of 1526 (81.1%) out of 1882 eligible individuals aged 85+ years. As part of a series of medical and ophthalmological examinations, we measured IOP upon non-contact tonometry.
Results :
The study included 1042 (68.3%) individuals with available IOP readings (mean age:88.1±2.7 years). Mean IOP was 14.6±5.3 mmHg (median:14 mmHg; range:6-60mmHg; 95%confidence interval (CI): 14.3,15.0) and 15.1±5.1mmHg (median:14mmHg; range:5-49mmHg; 95%CI: 14.8,15.4) in the right eyes and left eyes, respectively. In multivariable analysis, higher IOP was associated (regression coefficient r:0.35) with the systemic parameters of younger age (standardized regression coefficient beta:-0.08; non-standardized regression coefficient B:-0.13; 95%CI: -0.26, -0.01; P=0.04), female sex (beta:0.15; B:1.26; 95%CI:0.57,1.94; P=0.001) and higher systolic blood pressure (beta:0.18; B:0.03;95%CI:0.0.02,0.04; P<0.001), and the ocular parameters of thicker central corneal thickness (beta:0.18; B:0.02; 95%CI:0.01,0.03; P<0.001), longer axial length (beta:0.09; B:0.32;95%CI:0.05,0.60; P=0.02) and status after cataract surgery (beta:-0.13; B:-0.26; 95%CI:-1.59,-0.37;P=0.002). In that model, the IOP measurements increased by 0.19 mmHg (95%CI: 0.10,0.27) for each increase in central corneal thickness by 10 μm. In an univariate analysis, the IOP readings increased by 0.21 mmHg (95%CI: 0.13,0.29) for each increase in central corneal thickness by 10 μm.
Conclusions :
In this population-based recruited study population aged 85+ years, IOP decreased with older age and increased with blood pressure and was higher in females. As in younger populations, the IOP readings were dependent on central corneal thickness, increased with longer axial length and were lower in eyes after cataract surgery.
This is a 2021 ARVO Annual Meeting abstract.