June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Differences in retinal capillary blood flow and visual function in healthy male and female subjects of African and European descent
Author Affiliations & Notes
  • Brent A Siesky
    Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Alon Harris
    Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Nicholas Kalafatis
    Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Louis R Pasquale
    Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Aditya Belamkar
    Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Joshua D. Shin
    New York Medical College, Valhalla, New York, United States
  • Ingrida Januleviciene
    Eye Clinic, Medical Academy of Lithuanian University of Health Sciences, Kaunas, Lithuania
  • Giovanna Guidoboni
    University of Missouri, Columbia, Missouri, United States
  • Alice Chandra Verticchio Vercellin
    Icahn School of Medicine at Mount Sinai, New York, New York, United States
    Universita degli Studi di Pavia, Pavia, Lombardia, Italy
  • Footnotes
    Commercial Relationships   Brent Siesky, None; Alon Harris, Adom (S), Adom (C), AdOM (I), Luseed (C), Luseed (I), Oxymap (I), Phileas Pharma (S), Phileas Pharma (I), Qlaris (S), Qlaris (C), Qlaris (I), QuLent (I); Nicholas Kalafatis, None; Louis Pasquale, Emeral Bioscience (C), Eyenovia (C), Nicox (C), Twenty-twenty (C); Aditya Belamkar, None; Joshua Shin, None; Ingrida Januleviciene, Santen (C), Thea (C); Giovanna Guidoboni, Foresite LLC (C), Gspace LLC (I); Alice Chandra Verticchio Vercellin, None
  • Footnotes
    Support  NIH grant (R01EY030851), NSF-DMS (1853222/2021192), NIH Ro1 EY015473
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 548. doi:
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      Brent A Siesky, Alon Harris, Nicholas Kalafatis, Louis R Pasquale, Aditya Belamkar, Joshua D. Shin, Ingrida Januleviciene, Giovanna Guidoboni, Alice Chandra Verticchio Vercellin; Differences in retinal capillary blood flow and visual function in healthy male and female subjects of African and European descent. Invest. Ophthalmol. Vis. Sci. 2021;62(8):548.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate differences between retinal capillary blood flow and visual function in healthy male and female subjects of African (AD) and European (ED) descent.

Methods : A total of 201 healthy subjects (171 ED, 30 AD) were evaluated for: systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), intraocular pressure (IOP) measured via Goldmann applanation tonometry, and calculations of ocular perfusion pressures: (OPP=2/3MAP-IOP), systolic OPP (SOPP=SBP-IOP), diastolic OPP (DOPP=DBP-IOP), and mean OPP (MOPP=MAP-IOP). Retinal blood velocities and the percentage of measured area without active retinal capillary blood flow (estimated as % of retina with no detectable flow) in the superior (SNF) and inferior (INF) superficial retina were assessed with Heidelberg Retinal Flowmetry. Visual function was assessed with both Early Treatment Diabetic Retinopathy Study (ETDRS) and Vector Vision contrast sensitivity (CS) charts. Unpaired t-tests were performed with p<0.05 considered statistically significant.

Results : In all healthy subjects, the percentage non-vascularized retina was significantly higher in females compared to males in both the superior (SNF: 17.6%, vs. 15.5%; p=0.009) and inferior (INF: 18.1% vs. 14.6%; p=0.0002) superficial retina. There were no statistically significant differences in age between groups (female: 44.2 years, male: 43.3 years; p>0.05). The associated blood velocities were also significantly higher in females in both the superior and inferior retina (p=0.0003; p=0.0001, respectively). Healthy subjects of AD had significantly higher systemic blood pressures and all calculations of ocular perfusion pressures compared to those of ED (p<0.05). CS detection was significantly higher in males compared to females (CS Row D: 0.897 vs. 0.727; p=0.032) while ETDRS detection was significantly worse in females compared to males (0.133 vs. 0.084; p=0.044).

Conclusions : In this cohort of healthy subjects, females had a higher percentage of retinal avascular area and associated blood velocities in both the superior and inferior retina compared to males. Visual acuity and contrast sensitivity detection were also worse in females, while healthy subjects of AD had significantly higher blood and perfusion pressures than those of ED.

This is a 2021 ARVO Annual Meeting abstract.

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