Abstract
Purpose :
To report the clinical features, antibiotic sensitivities, and outcomes of Burkholderia cepacia associated endophthalmitis in three patients.
Methods :
The study design was a retrospective, observational case series.
Clinical and microbiology records were reviewed for patients evaluated at the Bascom Palmer Eye Institute and diagnosed with culture confirmed endophthalmitis due to B. cepacia. Antibiotic susceptibility profiles were generated using standard microbiologic protocols via an automated VITEK system.
Results :
Of 3 patients identified, endophthalmitis occurred in the setting of post penetrating keratoplasty (P1), following cataract surgery (P3), and after glaucoma filtering surgery (P2). Time from surgical procedure to presentation with endophthalmitis occurred on post-operative day 14 (P1) and month 5 (P2). In P3, infection occurred several years after cataract surgery but in the context of a possible direct orbital trauma. Presenting visual acuity (VA) ranged from hand motion to light perception. Initial treatment strategies were intravitreal ceftazidime and vancomycin injection together with fortified topical antibiotics (n = 2), and surgical repair of corneal defect and fortified topical antibiotics (n = 1). VA outcomes ranged from hand motion to no light perception, with two eyes ultimately requiring enucleation (P1 and P2), and P3 developing early phthisis bulbi at last follow up.
Conclusions :
Endophthalmitis caused by B. cepacia is a rare clinical entity with generally poor visual outcomes.
This is a 2021 ARVO Annual Meeting abstract.