June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Rate of endophthalmitis and associated risk factors following open globe injuries: A 17-year analysis
Author Affiliations & Notes
  • Asad Farooq Durrani
    Department of Ophthalmology and Visual Sciences, W K Kellogg Eye Center, Ann Arbor, Michigan, United States
  • Peter Yu Cheng Zhao
    Department of Ophthalmology and Visual Sciences, W K Kellogg Eye Center, Ann Arbor, Michigan, United States
  • Yunshu Zhou
    Department of Ophthalmology and Visual Sciences, W K Kellogg Eye Center, Ann Arbor, Michigan, United States
  • Michael J Huvard
    Department of Ophthalmology, University of Colorado Health, Aurora, Colorado, United States
  • Lyna Azzouz
    University of Michigan Medical School, Ann Arbor, Michigan, United States
  • Jason Michael Keil
    University of Michigan Medical School, Ann Arbor, Michigan, United States
  • Stephen T Armenti
    Department of Ophthalmology and Visual Sciences, W K Kellogg Eye Center, Ann Arbor, Michigan, United States
  • Vaidehi S Dedania
    Department of Ophthalmology, New York University School of Medicine, New York, New York, United States
  • David C Musch
    Department of Ophthalmology and Visual Sciences, W K Kellogg Eye Center, Ann Arbor, Michigan, United States
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, United States
  • David N Zacks
    Department of Ophthalmology and Visual Sciences, W K Kellogg Eye Center, Ann Arbor, Michigan, United States
  • Footnotes
    Commercial Relationships   Asad Durrani, None; Peter Zhao, None; Yunshu Zhou, None; Michael Huvard, None; Lyna Azzouz, None; Jason Keil, None; Stephen Armenti, None; Vaidehi Dedania, None; David Musch, None; David Zacks, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 1357. doi:
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      Asad Farooq Durrani, Peter Yu Cheng Zhao, Yunshu Zhou, Michael J Huvard, Lyna Azzouz, Jason Michael Keil, Stephen T Armenti, Vaidehi S Dedania, David C Musch, David N Zacks; Rate of endophthalmitis and associated risk factors following open globe injuries: A 17-year analysis. Invest. Ophthalmol. Vis. Sci. 2021;62(8):1357.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To assess risk factors for development of endophthalmitis following open globe injury.

Methods : A retrospective chart review of all patients treated for open globe injury at the University of Michigan from January 2000 through July 2017 was conducted. Exclusion criteria included intravitreal injection or intraocular surgery in the 30 days prior to injury or less than 30 days of follow-up. A total of 586 out of 993 eyes were included in the study. The main outcome measure was the rate of endophthalmitis in these eyes.

Results : 25/586 eyes (4.3%) presented with endophthalmitis, or developed endophthalmitis following globe closure. Of these, 12/25 eyes (48.0%) presented with endophthalmitis and 13/25 eyes (52.0%) developed endophthalmitis after globe closure. Multivariate logistic regression analysis identified time to globe repair (OR 4.5, CI 1.9-10.7, p = 0.0008), zone I injury (OR 3.6, CI 1.1-11.0, p = 0.0282), and need for additional surgery (OR 5.5, CI 1.5-19.7, p = 0.0092) as factors associated with increased risk of developing endophthalmitis. Subconjunctival antibiotics (OR 0.3, CI 0.1-0.7, p = 0.0036) were associated with decreased risk of developing endophthalmitis.

Conclusions : Prompt closure of the globe and use of subconjunctival antibiotics may reduce the risk of endophthalmitis in open globe injuries. Furthermore, a one-time dose of prophylactic antibiotics with same day discharge and delayed IOFB removal with intravitreal injection of antibiotics did not increase the rate of endophthalmitis. Open globe injuries can be visually devastating and understanding what factors predict and protect against endophthalmitis is paramount to achieving the best possible visual outcomes.

This is a 2021 ARVO Annual Meeting abstract.

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