June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
A Prospective study of type 1 and type 2 Diabetics examining the correlation between antioxidant levels and neuronal layer loss. (DECAN study)- An exploratory Study
Author Affiliations & Notes
  • LORRAINE NORTH
    Frimley Health NHS Foundation Trust, Frimley, Surrey, United Kingdom
  • Geeta V Menon
    Frimley Health NHS Foundation Trust, Frimley, Surrey, United Kingdom
  • Manju Chandran
    Frimley Health NHS Foundation Trust, Frimley, Surrey, United Kingdom
  • Footnotes
    Commercial Relationships   LORRAINE NORTH, None; Geeta Menon, None; Manju Chandran, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 1103. doi:
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      LORRAINE NORTH, Geeta V Menon, Manju Chandran; A Prospective study of type 1 and type 2 Diabetics examining the correlation between antioxidant levels and neuronal layer loss. (DECAN study)- An exploratory Study. Invest. Ophthalmol. Vis. Sci. 2021;62(8):1103.

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Abstract

Purpose : The aim of this study was to examine the relationship between retinal neuronal layer changes assessed using spectral domain optical coherence tomography (SD-OCT) with dietary intake of foods in patients with type 1 and type 2 diabetes with or without diabetic retinopathy.

Methods : Patients with type 1 and type 2 diabetes patients were recruited from the diabetic eye clinics at Frimley Park Hospital. A cross sectional study with a longitudinal element was carried out, 204 participants were recruited to the DECAN study. Outcome measures were dietary intake assessed using a food frequency questionnaire (FFQ), and optical coherence tomography (OCT).

Results : The results of the study showed that both outer nuclear layer (ONL) and the inner nuclear layer (INL) showed statistically significant associations with Vitamin B12, Pantothenic acid, copper and selenium. Selenium was seen to be associated with a thinner INL. The ONL showed a statistically significant association with vitamin B12, indicating that an increase in Vitamin B12 results in a thicker ONL whereas an increase in pantothenic acid is also associated with a thinner ONL.

Conclusions : This study has added to the growing evidence that oxidative stress, antioxidants and neurodegeneration are critical factors in the pathogenies of diabetic retinopathy early on.
The study showed promising results for further research that could lead to an interventional trial using a supplementation of selenium which has not been previously reported.

This is a 2021 ARVO Annual Meeting abstract.

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