June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Exposure to Porphyromonas gingivalis and Modifiable Risk Factors Modulates Risk for Early Diabetic Retinopathy
Author Affiliations & Notes
  • Chung-Jung Chiu
    The Forsyth Institute, Cambridge, Massachusetts, United States
  • Min-Lee Chang
    The Boston Children's Hospital, Boston, Massachusetts, United States
  • Alpdogan Kantarci
    The Forsyth Institute, Cambridge, Massachusetts, United States
  • Thomas E Van Dyke
    The Forsyth Institute, Cambridge, Massachusetts, United States
  • Wenyuan Shi
    The Forsyth Institute, Cambridge, Massachusetts, United States
  • Footnotes
    Commercial Relationships   Chung-Jung Chiu, None; Min-Lee Chang, None; Alpdogan Kantarci, None; Thomas Van Dyke, None; Wenyuan Shi, None
  • Footnotes
    Support  NIH Grant NEI R21EY028209 (C-JC) and NIDCR DE025020 (TEVD)
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 1945. doi:
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      Chung-Jung Chiu, Min-Lee Chang, Alpdogan Kantarci, Thomas E Van Dyke, Wenyuan Shi; Exposure to Porphyromonas gingivalis and Modifiable Risk Factors Modulates Risk for Early Diabetic Retinopathy. Invest. Ophthalmol. Vis. Sci. 2021;62(8):1945.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : We hypothesized that exposure to Porphyromonas gingivalis (P. g.) increases the risk for early diabetic retinopathy (DR) and that the risk can be modulated.

Methods : 116 early DR cases were identified, and 116 non-DR controls were selected randomly by frequency matching for age, sex, race, and education from the US Third National Health and Nutrition Examination Survey. DR was assessed using non-mydriatic fundus photographs and graded by trained graders using the Modified Airlie House Classification scheme and the Early Treatment for Diabetic Retinopathy Study severity scale. Serum P. g. immunoglobulin G (IgG) antibody (Ab) was measured in enzyme-linked immunosorbent assay units. Logistic regression was used to relate serum P. g. IgG Ab levels to the risk for early DR.

Results : Per tenfold increase in P. g. IgG Ab levels, there was an over 60% increased risk for early DR (odds ratio=1.64; 95% confident interval: 1.36 – 1.97) and a linear trend was noted for the estimated probabilities of early DR at various P. g. IgG Ab levels (p for trend=0.0053). The analysis also suggested that moderate alcohol consumption (less than 12 drinks in the past 12 months; p for interaction=0.0003) and maintaining a normal serum glycated hemoglobulin level (HbA1c≤5.7 %; p for interaction<0.0001) helped reduce the P. g.-related DR risk.

Conclusions : The increased P. g.-related DR risk could be alleviated by managing alcohol consumption and maintaining a normal blood glucose level. Findings from this study provide new directions for developing novel therapeutics and prevention strategies for DR.

This is a 2021 ARVO Annual Meeting abstract.

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