June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Self-Examination Low-Cost Full-Field OCT (SELFF-OCT) for Age-Related Macular Degeneration
Author Affiliations & Notes
  • Claus von der Burchard
    Department of Ophthalmology, Christian-Albrechts-Universitat zu Kiel Medizinische Fakultat, Kiel, Schleswig-Holstein, Germany
  • Helge Sudkamp
    Medizinisches Laserzentrum Lubeck GmbH, Lubeck, Schleswig-Holstein, Germany
  • Jan Tode
    Department of Ophthalmology, Christian-Albrechts-Universitat zu Kiel Medizinische Fakultat, Kiel, Schleswig-Holstein, Germany
    Department of Ophthalmology, Medizinische Hochschule Hannover, Hannover, Niedersachsen, Germany
  • Christoph Ehlken
    Department of Ophthalmology, Christian-Albrechts-Universitat zu Kiel Medizinische Fakultat, Kiel, Schleswig-Holstein, Germany
  • Konstantine Purtskhvanidze
    Department of Ophthalmology, Christian-Albrechts-Universitat zu Kiel Medizinische Fakultat, Kiel, Schleswig-Holstein, Germany
  • Moritz Moltmann
    Medizinisches Laserzentrum Lubeck GmbH, Lubeck, Schleswig-Holstein, Germany
  • Britta Heimes-Bussmann
    M3 Macula Monitor Münster, Augenzentrum am St. Franziskus-Hospital Münster, Münster, Germany
  • Peter Koch
    Medizinisches Laserzentrum Lubeck GmbH, Lubeck, Schleswig-Holstein, Germany
  • Michael Münst
    Medizinisches Laserzentrum Lubeck GmbH, Lubeck, Schleswig-Holstein, Germany
  • Malte vom Endt
    Medizinisches Laserzentrum Lubeck GmbH, Lubeck, Schleswig-Holstein, Germany
  • Timo Kepp
    Medizinisches Laserzentrum Lubeck GmbH, Lubeck, Schleswig-Holstein, Germany
  • Dirk Theisen-Kunde
    Medizinisches Laserzentrum Lubeck GmbH, Lubeck, Schleswig-Holstein, Germany
  • Inke König
    Institute of Medical Biometry and Statistics, University of Lübeck, Lübeck, Germany
  • Gereon Huttmann
    Medizinisches Laserzentrum Lubeck GmbH, Lubeck, Schleswig-Holstein, Germany
  • Johann Roider
    Department of Ophthalmology, Christian-Albrechts-Universitat zu Kiel Medizinische Fakultat, Kiel, Schleswig-Holstein, Germany
  • Footnotes
    Commercial Relationships   Claus von der Burchard, None; Helge Sudkamp, Visotec (P); Jan Tode, None; Christoph Ehlken, None; Konstantine Purtskhvanidze, None; Moritz Moltmann, Visotec (P); Britta Heimes-Bussmann, None; Peter Koch, Visotec (P); Michael Münst, Visotec (P); Malte vom Endt, None; Timo Kepp, None; Dirk Theisen-Kunde, None; Inke König, None; Gereon Huttmann, Visotec (P); Johann Roider, None
  • Footnotes
    Support  German Federal Ministry of Education and 35 Research (BMBF) Grant No. 13N13766
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 1927. doi:
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      Claus von der Burchard, Helge Sudkamp, Jan Tode, Christoph Ehlken, Konstantine Purtskhvanidze, Moritz Moltmann, Britta Heimes-Bussmann, Peter Koch, Michael Münst, Malte vom Endt, Timo Kepp, Dirk Theisen-Kunde, Inke König, Gereon Huttmann, Johann Roider; Self-Examination Low-Cost Full-Field OCT (SELFF-OCT) for Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2021;62(8):1927.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Self-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) is a novel OCT technology that was specifically designed for home monitoring of age-related macular degeneration (AMD). First clinical findings have been reported before [1]. This trial investigates an improved prototype for AMD patients and focusses on device operability and diagnostic accuracy compared with established spectral-domain OCT (SD-OCT).
[1] von der Burchard C et al. Self-examination low-cost full-field OCT (SELFF-OCT) for patients with various macular diseases. Graefes Arch Clin Exp Ophthalmol, 2020, DOI: 10.1007/s00417-020-05035-6.

Methods : We performed a cross-sectional study in patients with age-related macular degeneration. Patients received short training in device handling and then performed multiple self-scans with the SELFF-OCT according to a predefined protocol. Additionally, all eyes were examined with standard SD-OCT, performed by medical personnel. All images were graded in a reading center by at least 2 blinded investigators for different biomarkers and the necessity of anti-VEGF treatment.

Results : In total, 85 eyes of 45 patients with AMD were measured with SELFF-OCT. Compared to prior prototypes, advancements in technology and an improved patient interface enhanced image quality and reduced motion artifacts. In 86% of all examined eyes, OCT self-acquisition resulted in interpretable retinal OCT volume scans. In these patients, the sensitivity for detection of anti-VEGF treatment indication was 0.94 [confidence interval 0.79-0.99] and specificity 0.95 [0.82-0.99]. Sensitivity and specificity for the detection of single biomarkers were 0.9/0.98 for subretinal fluid, 0.57/0.95 for intraretinal fluid and 0.76/0.95 for pigment epithelium detachment.

Conclusions : SELFF-OCT was used successfully for retinal self-examination in most patients, and it could become a valuable tool for retinal home-monitoring in the future. Improvements are in progress to reduce device size and to improve handling, image quality and success rates.

This is a 2021 ARVO Annual Meeting abstract.

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