June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Comparison of macular pigment optical density measured with dual wavelength autofluorescence between 6° and 9° plateau references in non-advanced age-related macular degeneration and control patients
Author Affiliations & Notes
  • Archana Nigalye
    Department of Ophthalmology Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States
  • Raviv Katz
    Department of Ophthalmology Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States
  • Shrinivas Pundlik
    Department of Ophthalmology Harvard Medical School, Schepens Eye Research Institute of Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Tobias Elze
    Department of Ophthalmology Harvard Medical School, Schepens Eye Research Institute of Massachusetts Eye and Ear, Boston, Massachusetts, United States
  • Megan Kasetty
    Department of Ophthalmology Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States
  • Edward S Lu
    Department of Ophthalmology Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States
  • Ines Lains
    Department of Ophthalmology Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States
  • Vivian P Douglas
    Department of Ophthalmology Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States
  • Ivana K Kim
    Department of Ophthalmology Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States
  • Joan W Miller
    Department of Ophthalmology Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States
  • Demetrios G. Vavvas
    Department of Ophthalmology Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States
  • Deeba Husain
    Department of Ophthalmology Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States
  • John Brown Miller
    Department of Ophthalmology Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States
  • Footnotes
    Commercial Relationships   Archana Nigalye, None; Raviv Katz, None; Shrinivas Pundlik, None; Tobias Elze, None; Megan Kasetty, None; Edward Lu, None; Ines Lains, None; Vivian Douglas, None; Ivana Kim, Allergan (F), Biophytis (C), Castle Biosciences (C), Kodiak Sciences (C), Novartis (C); Joan Miller, Drusolv Therapeutics (S), Genentech/Roche (C), Genentech/Roche (R), Heidelberg Engineering (C), Heidelberg Engineering (R), KalVista Pharmaceuticals (C), KalVista Pharmaceuticals (R), Lowy Medical Research Institute (F), ONL Therapeutics (R), ONL Therapeutics (C), ONL Therapeutics (P), Sunovion (C), Sunovion (R), Valeant Pharmaceuticals/Mass. Eye and Ear (P), Valeant Pharmaceuticals/Mass. Eye and Ear (R); Demetrios Vavvas, Alcon Research Institute (F), Loefflers Family Foundation (F), National Eye Institute (F), Olix Pharmaceuticals, Inc (C), Research to Prevent Blindness (F), Valitor, Inc (C), Yeatts Family Foundation (F); Deeba Husain, Allergan (C), Commonwealth Grant (F), Genentech (C), Lions VisionGift (F), Macular Society (F), National Eye Institute (F), OMEICOS Ophthalmics, Inc. (C); John Miller, Alcon (C), Allergan (C), Genentech (C), Sunovion (C), Zeiss (C)
  • Footnotes
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Investigative Ophthalmology & Visual Science June 2021, Vol.62, 1910. doi:
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    • Get Citation

      Archana Nigalye, Raviv Katz, Shrinivas Pundlik, Tobias Elze, Megan Kasetty, Edward S Lu, Ines Lains, Vivian P Douglas, Ivana K Kim, Joan W Miller, Demetrios G. Vavvas, Deeba Husain, John Brown Miller; Comparison of macular pigment optical density measured with dual wavelength autofluorescence between 6° and 9° plateau references in non-advanced age-related macular degeneration and control patients. Invest. Ophthalmol. Vis. Sci. 2021;62(8):1910.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Macular Pigment Optical Density (MPOD) can be measured with Heidelberg Spectralis dual wavelength autofluorescence by setting the plateau reference at different perifoveal eccentricities, where the MPOD value is arbitrarily defined as zero. Previous studies have used different plateau references, and there is a lack of evidence whether the choice of plateau location affects MPOD measurements across various macular disorders. We compared the MPOD values obtained with 2 commonly used plateau references of 6° and 9° in non-advanced Age-Related Macular Degeneration (AMD) and control patients.

Methods : Cross-sectional study where we prospectively enrolled 295 eyes of 166 individuals; 210 with non-advanced AMD (19 early AMD, 191 intermediate AMD) and 85 controls (>50 years) after institutional IRB approval. Participants were imaged and classified with color fundus photographs for AMD (Age-Related Eye Disease Study classification). Imaging was performed using Heidelberg Spectralis dual wavelength autofluorescence. MPOD sum of volume at 2° (SoV-2o) values were calculated by setting plateau reference to 6° and 9°. A linear mixed-effects model was used to find association of the pairwise difference between SoV-2° values using 9° and 6° plateau references, with the various predictors of MPOD values, including age, presence of AMD, intra-ocular lens status, AREDS supplement use, and smoking history.

Results : On average, SoV-2o was 13% higher when calculated using the 9o reference plateau point (mean ± std. = 3227 ± 1172) instead of the 6o reference (mean ± std. = 2853 ± 1034), with 374 ± 315 as the mean ± std. within-eye pairwise difference between the two plateau references. The SoV-2° calculated for 9o and 6o references were highly correlated (R = 0.96, p < 0.001). The pairwise difference between SoV-2° calculated with the 9o and 6o reference was not associated with age, presence of AMD, intra-ocular lens status, AREDS supplement use, or smoking history.

Conclusions : The MPOD sum of volume measurements calculated using the 9o or 6o references appear to be equivalent in non-advanced AMD and control patients. This work will enable direct comparison of the findings between studies using different plateau references.

This is a 2021 ARVO Annual Meeting abstract.

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