June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Retinal Vessel Diameter Reductions in Pre-perimetric Glaucoma correlate with Pattern Electroretinogram and Foveal Avascular Zone Area Parameters
Author Affiliations & Notes
  • Corey Lacher
    Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, United States
  • Derek Orshan
    New York Institute of Technology, Old Westbury, New York, United States
  • Andrew Tirsi
    Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, United States
    Manhattan Eye Ear and Throat Institute, New York, New York, United States
  • Joby Tsai
    Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, United States
  • Vasiliki Gliagias
    Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, United States
  • Sofia Tello
    Rye High School, Rye, New York, United States
  • Peter H Derr
    Diopsys Inc., New York, United States
  • Sung Chul Park
    Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, United States
    Manhattan Eye Ear and Throat Institute, New York, New York, United States
  • Stephen A Obstbaum
    Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, United States
    Manhattan Eye Ear and Throat Institute, New York, New York, United States
  • Celso Tello
    Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, United States
    Manhattan Eye Ear and Throat Institute, New York, New York, United States
  • Footnotes
    Commercial Relationships   Corey Lacher, None; Derek Orshan, None; Andrew Tirsi, Northwell (C); Joby Tsai, None; Vasiliki Gliagias, None; Sofia Tello, None; Peter Derr, Diopsys Inc. (E); Sung Chul Park, None; Stephen Obstbaum, None; Celso Tello, Northwell (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 1850. doi:
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      Corey Lacher, Derek Orshan, Andrew Tirsi, Joby Tsai, Vasiliki Gliagias, Sofia Tello, Peter H Derr, Sung Chul Park, Stephen A Obstbaum, Celso Tello; Retinal Vessel Diameter Reductions in Pre-perimetric Glaucoma correlate with Pattern Electroretinogram and Foveal Avascular Zone Area Parameters. Invest. Ophthalmol. Vis. Sci. 2021;62(8):1850.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Recent literature suggests that average retinal vessel diameter is decreased in patients with open-angle glaucoma. We performed a prospective, observational cross-sectional study to determine whether changes in retinal vessel diameters were associated with steady state pattern electroretinogram (ssPERG) and Foveal Avascular Zone (FAZ) area parameters in patients with pre-perimetric glaucoma (PPG).

Methods : Five patients (8 eyes) with normal Humphrey 24-2 visual field tests, suspicious optic nerve head findings and with refractive errors < ± 5.0 Diopters were enrolled in the study conducted at Manhattan Eye Ear and Throat Hospital. Participants underwent comprehensive ophthalmological examination and tests on Humphrey Field Analyzer (HFA) , Diopsys NOVA PERG and the Cirrus HD OCT-A Angioplex devices. Average vessel diameter of retinal arteries and veins was calculated using the vessel analysis plug-in on ImageJ. FAZ area was determined using ImageJ. Correlation analyses among vessel diameters, FAZ area and ssPERG parameters [Magnitude (Mag), MagnitudeD (MagD) and MagD/Mag ratio], were assessed to characterize these associations (Pearson's). P values <0.05 considered statistically significant.

Results : Results were gathered from 8 eyes of 5 patients aged 59.90 ± 14.20 years of age, with mean IOP 18.30 ± 4.50 and HFA 24-2 mean deviation 0.21 +/- 0.94. Average vessel diameter was negatively correlated with FAZ area (r=-0.955, p<0.01) and positively correlated with both ssPERG parameters MagD (r= 0.733, p<0.05) and MagD/Mag ratio (r= 0.819, p<0.05). No associations were observed between vessel diameter and Mag. FAZ area was negatively associated with MagD, however, this relationship was not significant (r=-0.347, p=0.055).

Conclusions : To best of our knowledge, this is the first study to confirm the relationship between reductions in average vessel diameter measurements with abnormal ssPERG and enlarged FAZ area parameters in patients with PPG. These results suggest that retinal vascular abnormalities and retinal ganglion cell dysfunction may be present before changes in visual field tests. Future investigations are needed to better understand the relationships between arteriolar and venular diameters, as well as the effects of systemic diseases on vessel diameters.

This is a 2021 ARVO Annual Meeting abstract.

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