June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Sectorial Choroidal Assessment between Two Eyes of Healthy Subjects
Author Affiliations & Notes
  • Jay Chhablani
    University of Pittsburgh, Pittsburgh, Pennsylvania, United States
  • Gideon Nkrumah
    University of Pittsburgh, Pittsburgh, Pennsylvania, United States
  • Mohammed Abdul Rasheed
    University of Pittsburgh, Pittsburgh, Pennsylvania, United States
  • Oliver Beale
    University of Pittsburgh, Pittsburgh, Pennsylvania, United States
  • Filippo Tatti
    University of Pittsburgh, Pittsburgh, Pennsylvania, United States
  • Claudio Iovino
    University of Pittsburgh, Pittsburgh, Pennsylvania, United States
  • Kiran Kumar Vupparaboina
    University of Pittsburgh, Pittsburgh, Pennsylvania, United States
  • Asiya Jabeen
    University of Pittsburgh, Pittsburgh, Pennsylvania, United States
  • Enrico Peiretti
    University of Pittsburgh, Pittsburgh, Pennsylvania, United States
  • Footnotes
    Commercial Relationships   Jay Chhablani, None; Gideon Nkrumah, None; Mohammed Rasheed, None; Oliver Beale, None; Filippo Tatti, None; Claudio Iovino, None; Kiran Vupparaboina, None; Asiya Jabeen, None; Enrico Peiretti, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 1790. doi:
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      Jay Chhablani, Gideon Nkrumah, Mohammed Abdul Rasheed, Oliver Beale, Filippo Tatti, Claudio Iovino, Kiran Kumar Vupparaboina, Asiya Jabeen, Enrico Peiretti; Sectorial Choroidal Assessment between Two Eyes of Healthy Subjects. Invest. Ophthalmol. Vis. Sci. 2021;62(8):1790.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Choroidal vascularity index (CVI) and choroidal thickness (CT) are novel biomarkers for the evaluation of choroidal vasculature. Although well established, comparative analysis of CT and CVI at different choroidal sectors in healthy eyes have not been performed. Aim of this study was to compare the sectorial choroidal vascularity index and thickness of the macula between two eyes in healthy subjects

Methods : This prospective study included 50 eyes of 25 healthy subjects who underwent a comprehensive ophthalmic examination and enhanced-depth spectral-domain optical coherence tomography for both eyes. CVI and CT measurements were obtained using a validated algorithm for each sector using an early treatment diabetic retinopathy study map. A comparison of corresponding sectors between two eyes and multivariate analysis was performed.

Results : The mean age was 50.4 ± 13.2 years with 13 females and 12 males. There was no statistical difference in mean CVI and CT values between corresponding sectors of both eyes (central CVI P=0.74, CT P=0.77; inner superior CVI P=0.74, CT P=0.87; inner temporal CVI P= 0.87, CT P=0.80; inner nasal CVI P= 0.16, CT P=0.74; inner inferior CVI P=0.84, CT P=0.55 outer superior P=0.87, CT P=0.83; outer inferior P=0.89, CT P=0.68; outer temporal P= 0.72, CT P=0.83; outer nasal P= 0.66 CT P=0.90. Age was the only significant factor on multivariate regression (R2=0.31) Example of CVI maps of two eyes of the same subject has been uploaded as figure.

Conclusions : We report a significant positive relationship between age and sectoral values, whereas gender remained insignificant in both groups. Intra-sectoral (within the same eye) and inter- sectoral (between right and left eye) analysis of CT and CVI values yielded no significant difference. These results would be applicable to explore various chorioretinal diseases to evaluate sectoral choroidal changes.

This is a 2021 ARVO Annual Meeting abstract.

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