Abstract
Purpose :
To evaluate the diagnostic performance of the 8x8 grid of the posterior pole algorithm with two different fovea-to-disc inclinations to discriminate between healthy and primary open-angle glaucoma (POAG).
Methods :
85 eyes of 85 glaucomatous patients and 74 eyes of 74 early POAG patients were included. All underwent macular OCT scans (Spectralis, Heidelberg) using the 8x8 posterior pole algorithm with an automatic 7-degree inclination of the fovea-to-disc axis. Ganglion cell complex (GCC) thickness was obtained for the 64 superpixels of the grid. Then, horizontalization of the grid in each eye was performed and the results of GCC were also exported. The areas under the receiver operating characteristics curves (AUROC) values were obtained for the GCC thickness in the 64 cells for 7-degree inclined grid and for horizontalized grid. Heat maps were plotted to represent the AUROC values. The thickness of superpixels with AUROC values ≥0.75 were combined for each inclination obtaining a global index for the 7-degree inclined grid (7degINDEX) and the horizontalized grid (horINDEX).
Results :
AUROC values were ≥0.75 in 25 superpixels in the 7-degree inclined grid (the highest was the superpixel 2.8, AUROC=0.821) and 24 superpixels in the horizontalized grid (the highest was also the superpixel 2.8, AUROC=0.807). We found no significant difference between 7degINDEX AUROC (0.827) and horINDEX AUROC (0.824) (p>0.05, DeLong test).
Conclusions :
The 7-degree inclination of the 8x8 grid of the posterior pole algorithm measuring GCC thickness does not seem to outperform the horizontalized grid when discriminating between POAG and healthy eyes.
This is a 2021 ARVO Annual Meeting abstract.