June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Comparison of diagnosis accuracy of the ganglion cell complex thickness in the 7-degree inclined versus horizontalized 8x8 grid of the posterior pole algorithm to distinguish between healthy and glaucomatous eyes
Author Affiliations & Notes
  • Monica Del-Rio-Vellosillo
    Hospital Clinico Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain
  • Aurora Alvarez-Sarrion
    Hospital General Universitario Reina Sofia, Murcia, Murcia, Spain
  • Maria Dolores Lopez-Bernal
    Hospital General Universitario Jose M Morales Meseguer, Murcia, Murcia, Spain
  • Elena Rubio-Velazquez
    Hospital General Universitario Jose M Morales Meseguer, Murcia, Murcia, Spain
  • Maria D Pinazo-Duran
    Universitat de Valencia Facultat de Medicina i Odontologia, Valencia, Comunitat Valenciana, Spain
  • Jose Javier Garcia-Medina
    Hospital General Universitario Jose M Morales Meseguer, Murcia, Murcia, Spain
  • Footnotes
    Commercial Relationships   Monica Del-Rio-Vellosillo, None; Aurora Alvarez-Sarrion, None; Maria Dolores Lopez-Bernal, None; Elena Rubio-Velazquez, None; Maria Pinazo-Duran, None; Jose Javier Garcia-Medina, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 2462. doi:
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      Monica Del-Rio-Vellosillo, Aurora Alvarez-Sarrion, Maria Dolores Lopez-Bernal, Elena Rubio-Velazquez, Maria D Pinazo-Duran, Jose Javier Garcia-Medina; Comparison of diagnosis accuracy of the ganglion cell complex thickness in the 7-degree inclined versus horizontalized 8x8 grid of the posterior pole algorithm to distinguish between healthy and glaucomatous eyes. Invest. Ophthalmol. Vis. Sci. 2021;62(8):2462.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the diagnostic performance of the 8x8 grid of the posterior pole algorithm with two different fovea-to-disc inclinations to discriminate between healthy and primary open-angle glaucoma (POAG).

Methods : 85 eyes of 85 glaucomatous patients and 74 eyes of 74 early POAG patients were included. All underwent macular OCT scans (Spectralis, Heidelberg) using the 8x8 posterior pole algorithm with an automatic 7-degree inclination of the fovea-to-disc axis. Ganglion cell complex (GCC) thickness was obtained for the 64 superpixels of the grid. Then, horizontalization of the grid in each eye was performed and the results of GCC were also exported. The areas under the receiver operating characteristics curves (AUROC) values were obtained for the GCC thickness in the 64 cells for 7-degree inclined grid and for horizontalized grid. Heat maps were plotted to represent the AUROC values. The thickness of superpixels with AUROC values ≥0.75 were combined for each inclination obtaining a global index for the 7-degree inclined grid (7degINDEX) and the horizontalized grid (horINDEX).

Results : AUROC values were ≥0.75 in 25 superpixels in the 7-degree inclined grid (the highest was the superpixel 2.8, AUROC=0.821) and 24 superpixels in the horizontalized grid (the highest was also the superpixel 2.8, AUROC=0.807). We found no significant difference between 7degINDEX AUROC (0.827) and horINDEX AUROC (0.824) (p>0.05, DeLong test).

Conclusions : The 7-degree inclination of the 8x8 grid of the posterior pole algorithm measuring GCC thickness does not seem to outperform the horizontalized grid when discriminating between POAG and healthy eyes.

This is a 2021 ARVO Annual Meeting abstract.

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