June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
LONGITUDINAL ANALYSIS OF RETINAL AND BRAIN ATROPHY IN MULTIPLE SCLEROSIS
Author Affiliations & Notes
  • Heba Altarawneh
    Research Division, Weill Cornell Medicine - Qatar, Doha, Qatar
  • Ioannis N Petropoulos
    Research Division, Weill Cornell Medicine - Qatar, Doha, Qatar
  • Georgios Ponirakis
    Research Division, Weill Cornell Medicine - Qatar, Doha, Qatar
  • Adnan Khan
    Research Division, Weill Cornell Medicine - Qatar, Doha, Qatar
  • Hoda Y. Gad
    Research Division, Weill Cornell Medicine - Qatar, Doha, Qatar
  • Fatima Al-Shibani
    Research Division, Weill Cornell Medicine - Qatar, Doha, Qatar
  • Muhammad H Rehman
    Research Division, Weill Cornell Medicine - Qatar, Doha, Qatar
  • Dhabia Al-Merekhi
    Research Division, Weill Cornell Medicine - Qatar, Doha, Qatar
  • Karen John
    Research Division, Weill Cornell Medicine - Qatar, Doha, Qatar
  • Ahmed El-Sotouhy
    Hamad Medical Corporation, Doha, Ad Dawhah, Qatar
  • Ahmed Own
    Hamad Medical Corporation, Doha, Ad Dawhah, Qatar
  • Ashfaq Shuaib
    Medicine, University of Alberta Faculty of Medicine & Dentistry, Edmonton, Alberta, Canada
  • Dirk Dirk Deleu
    Hamad Medical Corporation, Doha, Ad Dawhah, Qatar
  • Beatriz Carcia Canibano
    Hamad Medical Corporation, Doha, Ad Dawhah, Qatar
  • Naveed Akhtar
    Hamad Medical Corporation, Doha, Ad Dawhah, Qatar
  • Rayaz A Malik
    Research Division, Weill Cornell Medicine - Qatar, Doha, Qatar
  • Footnotes
    Commercial Relationships   Heba Altarawneh, None; Ioannis Petropoulos, None; Georgios Ponirakis, None; Adnan Khan, None; Hoda Gad, None; Fatima Al-Shibani, None; Muhammad Rehman, None; Dhabia Al-Merekhi, None; Karen John, None; Ahmed El-Sotouhy, None; Ahmed Own, None; Ashfaq Shuaib, None; Dirk Dirk Deleu, None; Beatriz Canibano, None; Naveed Akhtar, None; Rayaz A Malik, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 2458. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Heba Altarawneh, Ioannis N Petropoulos, Georgios Ponirakis, Adnan Khan, Hoda Y. Gad, Fatima Al-Shibani, Muhammad H Rehman, Dhabia Al-Merekhi, Karen John, Ahmed El-Sotouhy, Ahmed Own, Ashfaq Shuaib, Dirk Dirk Deleu, Beatriz Carcia Canibano, Naveed Akhtar, Rayaz A Malik; LONGITUDINAL ANALYSIS OF RETINAL AND BRAIN ATROPHY IN MULTIPLE SCLEROSIS. Invest. Ophthalmol. Vis. Sci. 2021;62(8):2458.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Non-invasive quantification of retinal axonal and neuronal loss have been proposed as surrogate markers of axonal loss in multiple sclerosis (MS). We assessed their longitudinal relationship with measures of brain atrophy and disability.

Methods : Retinal nerve fiber layer (RNFL) thickness and total macular volume (TMV) were estimated in patients with MS (n=60) and age-matched, healthy controls (n=52) by optical coherence tomography (OCT) at baseline and 24-month follow-up. Brain volumes were quantified from cranial magnetic resonance imaging using NeuroQuant®. Neurological disability was assessed by means of the expanded disability status scale.

Results : In patients with MS compared to controls there was a significant reduction in RNFL (p<0.0001) and TMV (p=0.0004) at baseline. Specifically, RNFL was significantly reduced in the temporal-superior (p<0.0001), temporal (p<0.0001), temporal-inferior (p<0.0001), nasal-inferior (p=0.0005) and nasal-superior (p=0.001) aspects of the optic nerve. Patients with secondary progressive MS (SPMS) showed a greater reduction in RNFL (p=0.003) and TMV (P<0.0001) compared to patients with relapsing-remitting MS (RRMS). RNFL / TMV were significantly correlated (Pearson’s r) with grey matter (GM) (p=0.0003/p=0.0287), temporal lobe (TL) (p=0.0007/p=0.0287), thalamus (TH) (p=0.0001/p=0.0012), putamen (PU) (p<0.0001/p=0.0006) and whole brain (WB) (p= 0.0028/p=0.0206) volumes at baseline. At follow-up, there was a further significant reduction in temporal-inferior RNFL (p=0.009) and TMV (p=0.009). Patients with SPMS had significantly more advanced loss of RNFL (p=0.01) and TMV (p=0.02) compared to patients with RRMS. RNFL / TMV were significantly correlated with GM (p=0.0143/p=0.0449), TL (p=0.0141/p=0.0381), TH (p=0.0004/p=0.0019) PU (p<0.0001/p=0.0012) and WB (p=0.0015/p=0.0211) volume at follow-up. Patients with baseline TMV < 25th percentile (n= 12) showed a further significant reduction at follow-up in GM (p=0.02), TL (p=0.03), caudate (p=0.009), TH (p=0.0003), PU (0.009) and WB (p=0.001) volume. There was no significant relationship between retinal measures and clinical disability at baseline or follow-up.

Conclusions : There is a strong longitudinal relationship between retinal and brain atrophy in MS which further underpins the viability of OCT as a surrogate measure of axonal loss.

This is a 2021 ARVO Annual Meeting abstract.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×