June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Association between maternal and perinatal systemic factors and macular optical coherence tomography characteristics in preterm infants at 36 weeks postmenstrual age
Author Affiliations & Notes
  • Shwetha Mangalesh
    Duke University, Durham, North Carolina, United States
  • Neeru Sarin
    Duke University, Durham, North Carolina, United States
  • Brendan McGeehan
    University of Pennsylvania, Philadelphia, Pennsylvania, United States
  • Vincent Tai
    Duke University, Durham, North Carolina, United States
  • Liangbo Shen
    Yale University School of Medicine, New Haven, Connecticut, United States
  • Xi Chen
    Duke University, Durham, North Carolina, United States
  • Noelle Younge
    Duke University, Durham, North Carolina, United States
  • C. Michael Cotten
    Duke University, Durham, North Carolina, United States
  • Suzanne Michalak
    Duke University, Durham, North Carolina, United States
  • Lejla Vajzovic
    Duke University, Durham, North Carolina, United States
  • Gui-Shuang Ying
    University of Pennsylvania, Philadelphia, Pennsylvania, United States
  • Cynthia A Toth
    Duke University, Durham, North Carolina, United States
  • Footnotes
    Commercial Relationships   Shwetha Mangalesh, None; Neeru Sarin, None; Brendan McGeehan, None; Vincent Tai, None; Liangbo Shen, None; Xi Chen, None; Noelle Younge, None; C. Cotten, None; Suzanne Michalak, None; Lejla Vajzovic, None; Gui-Shuang Ying, None; Cynthia Toth, Alcon (R), Duke University (P), Hemosonics (R), Theia Imaging, LLC (I)
  • Footnotes
    Support  NIH: RO1 EY025009, P30 EY005722, K23 EY02827
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 2447. doi:
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      Shwetha Mangalesh, Neeru Sarin, Brendan McGeehan, Vincent Tai, Liangbo Shen, Xi Chen, Noelle Younge, C. Michael Cotten, Suzanne Michalak, Lejla Vajzovic, Gui-Shuang Ying, Cynthia A Toth; Association between maternal and perinatal systemic factors and macular optical coherence tomography characteristics in preterm infants at 36 weeks postmenstrual age. Invest. Ophthalmol. Vis. Sci. 2021;62(8):2447.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the associations between maternal and perinatal systemic health factors and macular optical coherence tomography (OCT) characteristics in preterm infants at 36 weeks postmenstrual age (PMA).

Methods : We included 85 infants enrolled under STudy of Eye imaging in Preterm infantS (BabySTEPS, NCT02887157) with parental consent for research and OCT imaging at 36±1 weeks PMA. We evaluated associations between maternal and perinatal systemic factors and, vitreous pathologies, macular edema, and the following layer thicknesses at the foveal center and 1000µm nasal to the fovea: total retina, combined retinal nerve fiber layer (RNFL), ganglion cell layer (GCL) and inner plexiform layer (IPL), inner nuclear layer (INL), and outer retina. We averaged the thicknesses of the right and left eyes for all infants and tested the associations using multivariable regression models.

Results : Infants with lower gestational ages had thicker foveal RNFL+GCL+IPL (estimate=-4.76µm, 95% confidence interval=-6.12, -3.37; p=<0.001) and those with intracranial hemorrhage/periventricular leukomalacia/ventriculomegaly (n=30) had thinner RNFL+GCL+IPL at 1000µm nasal from fovea (mean± standard deviation = 124±3 versus 134±2µm, 0.004). Infants with septicemia/necrotizing enterocolitis (NEC) (n=16) had a significantly thicker outer retina (110±7 vs. 79±3µm, p=<0.001) and total retina (316±27 vs. 222±13µm, p=0.002) at the fovea and thicker INL (98±7 vs. 76±3µm, p=0.006) at 1000µm nasal from fovea. These associations remained statistically significant after adjusting for confounding variables such as gestational age.

Conclusions : Lower gestational age and intracranial hemorrhage/periventricular leukomalacia/ventriculomegaly independently impact inner retinal layers other than the INL. Parafoveal INL devoid of distorting cystoid spaces, and outer and total retinal thicknesses at the foveal center are affected by septicemia/NEC. Our study highlights the variable effects of different systemic health on preterm retina, independent of prematurity related birth factors.

This is a 2021 ARVO Annual Meeting abstract.

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