June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Intraoperative Retinal Changes May Predict Surgical Outcomes After Epiretinal Membrane Peeling
Author Affiliations & Notes
  • Jaycob Avaylon
    California Northstate University College of Medicine, Elk Grove, California, United States
  • Lekha Mukkamala
    Department of Ophthalmology and Vision Science, University of California Davis, Sacramento, California, United States
  • Robert Welch
    Department of Ophthalmology and Vision Science, University of California Davis, Sacramento, California, United States
  • Amirfarbod Yazdanyar
    Department of Ophthalmology and Vision Science, University of California Davis, Sacramento, California, United States
  • Parisa Emami-Naeini
    Department of Ophthalmology and Vision Science, University of California Davis, Sacramento, California, United States
  • Sophia Wong
    Department of Ophthalmology and Vision Science, University of California Davis, Sacramento, California, United States
  • Jordan Storkersen
    California Northstate University College of Medicine, Elk Grove, California, United States
  • Jessica Loo
    Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States
  • David Cunefare
    Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States
  • Sina Farsiu
    Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States
  • Ala Morshiri
    Department of Ophthalmology and Vision Science, University of California Davis, Sacramento, California, United States
  • Susanna S Park
    Department of Ophthalmology and Vision Science, University of California Davis, Sacramento, California, United States
  • Glenn Yiu
    Department of Ophthalmology and Vision Science, University of California Davis, Sacramento, California, United States
  • Footnotes
    Commercial Relationships   Jaycob Avaylon, None; Lekha Mukkamala, None; Robert Welch, None; Amirfarbod Yazdanyar, None; Parisa Emami-Naeini, None; Sophia Wong, None; Jordan Storkersen, None; Jessica Loo, None; David Cunefare, None; Sina Farsiu, None; Ala Morshiri, None; Susanna Park, None; Glenn Yiu, Allergan (C), Carl Zeiss Meditec (C), Clearside Biomedical (C), Genentech (C), Intergalactic Therapeutics (C), Iridex (C), Regeneron (C), Topcon (C), Verily (C)
  • Footnotes
    Support  GY has research support from NIH K08 EY026101, NIH R21 EY031108, the BrightFocus Foundation, the E Matilda Ziegler Foundation, and the Macula Society. AM is supported by NIH K08 EY027463. SF is supported by NIH P30 EY005722, Google Faculty Research Award, and 2018 Unrestricted Grant from Research to Prevent Blindness.
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 2434. doi:
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      Jaycob Avaylon, Lekha Mukkamala, Robert Welch, Amirfarbod Yazdanyar, Parisa Emami-Naeini, Sophia Wong, Jordan Storkersen, Jessica Loo, David Cunefare, Sina Farsiu, Ala Morshiri, Susanna S Park, Glenn Yiu; Intraoperative Retinal Changes May Predict Surgical Outcomes After Epiretinal Membrane Peeling. Invest. Ophthalmol. Vis. Sci. 2021;62(8):2434.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate if intraoperative retinal changes during epiretinal membrane (ERM) peeling affect anatomic or functional outcomes after surgery.

Methods : We measured retinal thickness using an intraoperative optical coherence tomography (iOCT) device in patients undergoing pars plana vitrectomy with membrane peeling for idiopathic ERM. Changes in intraoperative central macular thickness (iCMT) were compared with postoperative improvements in CMT and best-corrected visual acuity (VA).

Results : 27 eyes from 27 patients (mean age 68 years) underwent iOCT-assisted ERM peeling surgery. Before surgery, mean VA was logMAR 0.50±0.36 (Snellen 20/63) and mean baseline CMT was 489±82 µm. Mean iCMT before peeling was 477±87 µm, which correlated well with preoperative CMT (P<0.001). Mean change in iCMT was -39.6±37μm (range -116 to +77μm). After surgery, VA improved to logMAR 0.40±0.38 (Snellen 20/50) at month 1 and logMAR 0.27±0.23 (Snellen 20/37) at month 3, while CMT decreased to 397±44μm and 396±51μm at months 1 and 3. Eyes that underwent greater amount of iCMT change (absolute value of iCMT change) were associated with greater CMT reduction at month 1 (P<0.001) and month 3 (P=0.010), while those with greater intraoperative thinning (actual iCMT change) showed a trend toward better VA outcomes at months 1 (P=0.054) and 3 (P=0.036).

Conclusions : Intraoperative changes in retinal thickness may predict anatomic and visual outcomes after idiopathic ERM peeling surgery.

This is a 2021 ARVO Annual Meeting abstract.

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