June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Macular thickness and vessel density in glaucoma eyes with and without high axial myopia
Author Affiliations & Notes
  • Jasmin Rezapour
    Ophthalmology, University of California San Diego, La Jolla, California, United States
    Ophthalmology, Johannes Gutenberg Universitat Mainz, Mainz, Rheinland-Pfalz, Germany
  • Christopher Bowd
    Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Jade Dohleman
    Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Akram Belghith
    Ophthalmology, University of California San Diego, La Jolla, California, United States
  • James A Proudfoot
    Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Mark Christopher
    Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Leslie Hyman
    Ophthalmology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States
  • Jost Jonas
    Opthalmology, Ruprecht Karls Universitat Heidelberg, Heidelberg, Baden-Württemberg, Germany
  • Rafaella Penteado
    Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Sasan Moghimi
    Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Huiyuan Hou
    Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Massimo A Fazio
    Ophthalmology and Vision Science, The University of Alabama at Birmingham, Birmingham, Alabama, United States
    Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, Alabama, United States
  • Robert N Weinreb
    Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Linda M Zangwill
    Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Footnotes
    Commercial Relationships   Jasmin Rezapour, None; Christopher Bowd, None; Jade Dohleman, None; Akram Belghith, None; James Proudfoot, None; Mark Christopher, None; Leslie Hyman, None; Jost Jonas, None; Rafaella Penteado, None; Sasan Moghimi, None; Huiyuan Hou, None; Massimo Fazio, None; Robert Weinreb, Aerie Pharmaceuticals (C), Allergan (C), Bausch&Lomb (C), Bausch&Lomb (F), Carl Zeiss Meditec (F), Centervue (F), Eyenovia (C), Genentech (F), Heidelberg Engineering (F), Konan Medical (F), Meditec-Zeiss (P), Optos (F), Optovue (F), Toromedes (P), Unity (C); Linda Zangwill, Carl Zeiss Meditec Inc. (F), Heidelberg Engineering (R), Heidelberg Engineering GmbH (F), Optovue Inc. (F), Topcon Medical Systems Inc (F), Zeiss Meditec (P)
  • Footnotes
    Support  Jasmin Rezapour: German Research Foundation research fellowship grant recipient (RE 4155/1-1) and German Ophthalmological Society Grant, Mark Christopher: EY030942, K99EY030942, Sasan Moghimi: TOBACCO-RELATED DISEASE RESEARCH PROGRAM T31IP1511, Rober N. Weinreb: National Eye Institute R01EY029058, Unrestricted grant from Research to Prevent Blindness, New YorkNational Eye Institute R01EY029058, Unrestricted grant from Research to Prevent Blindness, New York, Linda M. Zangwill: National Eye Institute R01EY11008, R01EY19869, R01EY027510, P30EY022589
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 2431. doi:
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    • Get Citation

      Jasmin Rezapour, Christopher Bowd, Jade Dohleman, Akram Belghith, James A Proudfoot, Mark Christopher, Leslie Hyman, Jost Jonas, Rafaella Penteado, Sasan Moghimi, Huiyuan Hou, Massimo A Fazio, Robert N Weinreb, Linda M Zangwill; Macular thickness and vessel density in glaucoma eyes with and without high axial myopia. Invest. Ophthalmol. Vis. Sci. 2021;62(8):2431.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the association between various macular layer thicknesses and superficial vessel density measurements and both axial length (AL) and glaucoma severity to improve glaucoma detection in highly myopic eyes.

Methods : 248 glaucoma patients (401 eyes) with AL measurements and macular optical coherence tomography (OCT) imaging were stratified into three axial myopia groups of no- (146 eyes), mild- (208 eyes) and high-axial myopia (AL > 26mm) (47 eyes). Ganglion cell inner plexiform layer (GCIPL) thickness, macular retinal nerve fiber layer (mRNFL) thickness, ganglion cell complex (GCC) thickness and the macular superficial vessel density (sVD) were measured with the built-in software and macular choroidal thickness (mCT) was assessed using deep learning strategies for each axial myopia group. Univariate and age- and VFMD-adjusted models were assessed to evaluate the association between structural measures and AL and VFMD.

Results : Thinner global GCIPL and GCC were not associated with AL (p<0.350) but were significantly associated with visual field mean deviation (VFMD) (R2=35.1; and R2=33.4; respectively p<0.001). Thicker mRNFL showed a weak association with larger AL (R2=3.4; p=0.001) and a positive association with VFMD (global R2=20.5; p<0.001). Lower sVD was moderately associated with worse VFMD (R2=31.8; p<0.001) and weakly associated with larger AL (R2=2.3; p=0.016). Thinner MCT was not associated with VFMD (P=0.262) but was associated with larger AL (R2=17.3; p<0.001).

Conclusions : Thinner GCIPL and GCC were associated with more severe glaucoma and were not associated with AL suggesting that these measurements might be useful for glaucoma detection in myopic eyes.

This is a 2021 ARVO Annual Meeting abstract.

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