Investigative Ophthalmology & Visual Science Cover Image for Volume 62, Issue 8
June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Multifocal VEP measurements in healthy aging subjects reveal correlations with RNFL changes in OCT and cognitive assessment
TING SHEN; Samran Sheriff; Angela Schulz; Yuyi You; Stuart L Graham; Vivek Kumar Gupta
Author Affiliations & Notes
  • TING SHEN
    Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia
    The University of Sydney Save Sight Institute, Sydney, New South Wales, Australia
  • Samran Sheriff
    Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia
  • Angela Schulz
    Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia
  • Yuyi You
    Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia
    The University of Sydney Save Sight Institute, Sydney, New South Wales, Australia
  • Stuart L Graham
    Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia
    The University of Sydney Save Sight Institute, Sydney, New South Wales, Australia
  • Vivek Kumar Gupta
    Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia
  • Footnotes
    Commercial Relationships   TING SHEN, None; Samran Sheriff, None; Angela Schulz, None; Yuyi You, None; Stuart Graham, None; Vivek Kumar Gupta, None
  • Footnotes
    Support  NHMRC
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 2409. doi:
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      TING SHEN, Samran Sheriff, Angela Schulz, Yuyi You, Stuart L Graham, Vivek Kumar Gupta; Multifocal VEP measurements in healthy aging subjects reveal correlations with RNFL changes in OCT and cognitive assessment. Invest. Ophthalmol. Vis. Sci. 2021;62(8):2409.

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Abstract

Purpose : The cortex and the retina share many characteristics, including embryologic origin, biochemistry, neurotransmitter communication and microvasculature. To better understand whether visual pathway changes reflect a relationship with cognitive function, we evaluated correlation between retinal structural (OCT), neuropsychological (trail making test, TMT; digit span) and visual functional (multifocal visual evoked potentials, mfVEP) measurements in healthy aging subjects.

Methods : In this cross-sectional, observational clinical study, 74 healthy participants with a mean (SD) age of 67.5 (9.0) years were enrolled from the Optic Nerve and Cognitive Decline (ONDCC) study. All participants underwent OCT peripapillary ring scan protocol for RNFL analysis and mfVEP for amplitude and latency assessment. They were also subjected to TMT testing for attention and executive function and digit span neuropsychological examination for working memory assessment. A total of 148 eyes were included for correlation analysis between OCT and mfVEP. Averaged mfVEP measures were used to analyze the relationship with TMT. Correlations between OCT, TMT and mfVEP parameters were analyzed using partial correlation and controlled for age and gender (P < 0.05).

Results : At study entry, a significant correlation between digit span total score and mfVEP latency (r = 0.39, P = 0.001) was observed. The mfVEP amplitude showed mild but significant correlations with global (r = 0.25, P = 0.005), temporal superior (r = 0.18, P = 0.05), temporal inferior (r = 0.23, P = 0.01) and nasal inferior (r = 0.3, P = 0.001) sectoral RNFL thickness. The TMT-test A also demonstrated negative correlation with mfVEP amplitude (r = -0.26, P = 0.04).

Conclusions : Our results suggested a significant correlation between mfVEP latency and working memory. MfVEP amplitude was also significantly correlated with global and sectoral RNFL thickness changes as measured by OCT as well as cognitive function characterized by the attention and executive function assessments. These findings indicate that the mfVEP measurements may parallel cognitive decline in the aging population. Further studies are planned in confirmed cognitively impaired subjects.

This is a 2021 ARVO Annual Meeting abstract.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Copyright © 2025 Association for Research in Vision and Ophthalmology.
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