June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Functional tests and ganglion cell complex measured with optical coherence tomography in Autosomal Dominant Optic Atrophy.
Author Affiliations & Notes
  • Anna Camos-Carreras
    Ophthalmology, Hospital Clinic de Barcelona, Barcelona, Barcelona, Spain
  • Marc Figueras-Roca
    Ophthalmology, Hospital Clinic de Barcelona, Barcelona, Barcelona, Spain
  • Salut Alba-Arbalat
    Ophthalmology, Hospital Clinic de Barcelona, Barcelona, Barcelona, Spain
  • Marina Dotti-Boada
    Ophthalmology, Hospital Clinic de Barcelona, Barcelona, Barcelona, Spain
  • Bernardo Sanchez-Dalmau
    Ophthalmology, Hospital Clinic de Barcelona, Barcelona, Barcelona, Spain
  • Footnotes
    Commercial Relationships   Anna Camos-Carreras, None; Marc Figueras-Roca, None; Salut Alba-Arbalat, None; Marina Dotti-Boada, None; Bernardo Sanchez-Dalmau, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 2398. doi:
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      Anna Camos-Carreras, Marc Figueras-Roca, Salut Alba-Arbalat, Marina Dotti-Boada, Bernardo Sanchez-Dalmau; Functional tests and ganglion cell complex measured with optical coherence tomography in Autosomal Dominant Optic Atrophy.. Invest. Ophthalmol. Vis. Sci. 2021;62(8):2398.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate ganglion cell complex (GCC) and retinal nerve fiber layer (RNFL) with optical coherence tomography (OCT) and functional tests as visual acuity (VA) and Hardy Rand and Rittler (HRR) Standard Pseudoisochromatic Test in patients with Autosomal Dominant Optic Atrophy (ADOA).

Methods : Prospectively defined, cross-sectional study of 38 eyes of 19 patients with diagnosis of ADOA. All patients underwent a complete functional examination with VA and colour test, and a structural examination with OCT (Cirrus®, Zeiss).

Results : Analisis of OCT results was done and correlated with functional tests. Results show that temporal sectors of GCC and inferior and superior RNFL sectors were directly correlated with VA measured with ETDRS and with HRR in eyes with ADOA.

Conclusions : Functional and morphologic changes observed in ADOA eyes are helpful to understand the physiology of the disease. Analizing OCT, VA and colour test could be a future tool to select patients who can take benefit of receiving future treatments.

This is a 2021 ARVO Annual Meeting abstract.

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