June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Ultrasonic Assessment of Gaze-Induced Deformation of Posterior Staphyloma in Highly Myopic Eyes by Means of a Semi-Automated Assessment of Local Radius of Curvature
Author Affiliations & Notes
  • Quan V Hoang
    Singapore Eye Research Institute, Singapore National Eye Centre, Duke-NUS, Singapore
    Ophthalmology, Columbia University Irving Medical Center, New York, New York, United States
  • Ronald H Silverman
    Ophthalmology, Columbia University Irving Medical Center, New York, New York, United States
  • Daryle Jason Go Yu
    Singapore Eye Research Institute, Singapore National Eye Centre, Duke-NUS, Singapore
  • Yee Shan Dan
    Singapore Eye Research Institute, Singapore National Eye Centre, Duke-NUS, Singapore
  • Isabella Loh
    Singapore Eye Research Institute, Singapore National Eye Centre, Duke-NUS, Singapore
  • Theresa H Lye
    F. L. Lizzi Center for Biomedical Engineering, Riverside Research, New York, New York, United States
  • Kai Yuan Tey
    Singapore Eye Research Institute, Singapore National Eye Centre, Duke-NUS, Singapore
  • Jonathan Mamou
    F. L. Lizzi Center for Biomedical Engineering, Riverside Research, New York, New York, United States
  • Kazuyo Ito
    Singapore Eye Research Institute, Singapore National Eye Centre, Duke-NUS, Singapore
  • Footnotes
    Commercial Relationships   Quan Hoang, None; Ronald Silverman, None; Daryle Jason Yu, None; Yee Shan Dan, None; Isabella Loh, None; Theresa Lye, None; Kai Yuan Tey, None; Jonathan Mamou, None; Kazuyo Ito, None
  • Footnotes
    Support  This work was supported in part by the National Institutes of Health (EY023595 (QVH), EB028084 (JM), and unrestricted grant from Research to Prevent Blindness to the Dept. of Ophthalmology of Columbia University and the Singapore National Medical Research Council (CSA/MOH-000151/2019 (QVH)).
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 2275. doi:
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      Quan V Hoang, Ronald H Silverman, Daryle Jason Go Yu, Yee Shan Dan, Isabella Loh, Theresa H Lye, Kai Yuan Tey, Jonathan Mamou, Kazuyo Ito; Ultrasonic Assessment of Gaze-Induced Deformation of Posterior Staphyloma in Highly Myopic Eyes by Means of a Semi-Automated Assessment of Local Radius of Curvature. Invest. Ophthalmol. Vis. Sci. 2021;62(8):2275.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Ultrasound is a commonly available tool to assess the properties of the posterior eye, allowing us to characterize morphological changes and mechanical properties with kinetic exam. Here, we determine if the stress and strain of eye movements result in gaze-induced deformation of posterior staphyloma in highly myopic (HM) eyes.

Methods : A prospective imaging study was performed on 101 HM eyes (axial length range: 27.0 to 39.3 mm) of 52 patients with a clinical diagnosis of posterior staphyloma. 10 MHz B-scan ultrasound images oriented along the visual axis were acquired while subjects fixated in 5 directions (primary, nasal, temporal, down and up gaze). An algorithm was used to assess the local radius of curvature (K in mm-1). Specifically, an intensity-based segmentation algorithm tracked the vitreoretinal boundary and calculated K using differential calculus applied to the traced boundary. Positive K implies anterior convexity, whereas negative K implies posterior convexity. Larger K value implies a greater spatial change. The standard deviation (std) of K represents the level of non-uniformity along the curve of the entire posterior wall. One static frame for each scan direction was chosen to calculate the average and std of K in each direction. The Kruskal-Wallis test with the Tukey-Kramer method (as post hoc multiple comparisons) was performed to assess statistical significance between groups.

Results : Overall, we found significant gaze-induced posterior eye shape changes among the different gazes when grouped together (p < 0.001). Specifically, among the vertical scans, the average K in upgaze was 0.019 mm-1 greater than in primary gaze (p < 0.001). Also, the average K in upgaze was 0.021 mm-1 greater than in downgaze (p < 0.001). Std of K in upgaze was 0.081 mm-1 greater than in primary gaze (p < 0.001). Also, std of K in upgaze was 0.058 mm-1 greater than in downgaze (p < 0.001). There were no significant gaze-induced posterior eye shape changes with horizontal eye movements (all p > 0.05).

Conclusions : Significant gaze-induced staphyloma deformation was confirmed by ultrasound B-scan-based assessment, which is consistent with studies suggesting the association of environmental factors, such as excessive nearwork, with myopia development and progression.

This is a 2021 ARVO Annual Meeting abstract.

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