June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Accommodation study 1: Novel physiological changes in anterior segment structures during real-time long-range accommodation
Author Affiliations & Notes
  • Amar Pujari
    Ophthalmology, All India Institute of Medical Sciences, New Delhi, Delhi, India
  • Sujeeth Modaboyina
    Ophthalmology, All India Institute of Medical Sciences, New Delhi, Delhi, India
  • Suresh Yadav
    Ophthalmology, All India Institute of Medical Sciences, New Delhi, Delhi, India
  • Ramanjit Sihota
    Ophthalmology, All India Institute of Medical Sciences, New Delhi, Delhi, India
  • Pradeep Sharma
    Ophthalmology, All India Institute of Medical Sciences, New Delhi, Delhi, India
  • Namrata Sharma
    Ophthalmology, All India Institute of Medical Sciences, New Delhi, Delhi, India
  • Tanuj Dada
    Ophthalmology, All India Institute of Medical Sciences, New Delhi, Delhi, India
  • Jeewan Titiyal
    Ophthalmology, All India Institute of Medical Sciences, New Delhi, Delhi, India
  • Footnotes
    Commercial Relationships   Amar Pujari, None; Sujeeth Modaboyina, None; Suresh Yadav, None; Ramanjit Sihota, None; Pradeep Sharma, None; Namrata Sharma, None; Tanuj Dada, None; Jeewan Titiyal, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 2898. doi:
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      Amar Pujari, Sujeeth Modaboyina, Suresh Yadav, Ramanjit Sihota, Pradeep Sharma, Namrata Sharma, Tanuj Dada, Jeewan Titiyal; Accommodation study 1: Novel physiological changes in anterior segment structures during real-time long-range accommodation. Invest. Ophthalmol. Vis. Sci. 2021;62(8):2898.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To systematically study anterior segment changes during dynamic, long-range accommodation.

Methods : Design: Prospective, observational study.

Participants: A total of 26 young, healthy, third-decade subjects with less than ±0.5D refractive error.

Methods: On swept-source anterior segment optical coherence tomography (CASIA-2, Tomey Corp, Japan), anterior segment structural changes were recorded on accommodation, from baseline (0 diopter) to 8 diopters.

Main outcome measures: Software generated automated changes in corneal thickness and volume, anterior chamber depth and area, iris area and curvature, lens curvature, lens thickness, lens tilt and decentration at each diopter, and qualitative changes in the ciliary body were noted.

Results : Results: 52 eyes of 26 subjects were evaluated, with mean age of 25.92±1.64 years. Each successive dioptric accommodative stimulus from baseline, lead to progressive decremental responses in anterior lens curvature (p<0.001), posterior lens curvature (p<0.001), anterior chamber depth (p<0.001) and anterior chamber area (p=<0.05) with corresponding, incremental responses in lens thickness (p<0.001) noted till 8D. However, the overall and inter-dioptric responses were more significant during the initial phases of stimulation, up to 4D, as compared to later. Likewise, iris (nasal and temporal) curvature (p<0.001) and area (p<0.001) also showed dynamic changes in a coordinated manner. Cornea and anterior chamber width changes were statistically insignificant, even though fluctuations were noted at higher dioptres.

Conclusions : Conclusions: On progressively increasing accommodation, initial significant changes were seen as primarily lenticular, complementary anterior chamber and associated iris changes. Whereas, accommodation at higher diopters showed significantly altered lens position and other complex anterior segment structural changes.

This is a 2021 ARVO Annual Meeting abstract.

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