Abstract
Purpose :
To study the relationship between the retinal shape measured using OCT and the off-axis refractive error in adults.
Methods :
A prospective clinical study was performed including the 32 eyes of 16 adult subjects at the age of 23-62 years old (age 39.00±13.22; mean±SD, SE = -3.15±2.38 D) have been examined using an OCT with auto-alignment (3D-OCT-1 Maestro, Topcon, Tokyo) and retinal shape modeling (prototype software, Topcon, Tokyo) functions. The RPE position in horizontal 12mm scans centered on the fovea was used to represent retinal shape after alignment correction considering corneal curvature, axial length, and eye movement. The off-axis refraction data were obtained from an open-view auto refractometer (Grand Seiko, Japan) by measurements from 5 angles in the horizontal plane (-30°, -15°, 0°, 15°, 30°). Both retinal shape profiles and the refraction levels were then fitted into curves, and the first order (slope) and the second order (curvature) coefficients were used for the analysis.
Results :
We found strong correlations between the slopes of left and right eye in the OCT retinal shape data between left and right eye in slopes (CC = -0.903 p-value < 0.001), in curvatures (CC = 0.893, p-value < 0.001). In the off-axis refraction data fitting the slopes (CC = -0.511, p-value = 0.061) relation was not significant, while curvatures (CC= 0.736, p-value = 0.003) correlated strong between left and right eyes, conforming the expected properties. In relations between the retinal shape model and the levels of refraction fitting we discovered significant correlations of the curvatures in the right eyes (CC = 0.657, p-value = 0.045) and the left (CC = 0.774, p-value = 0.001).
Conclusions :
Both OCT retinal shape model fitting and off-axis refraction error fitting confirm the expected properties, such as contralateral reflective symmetry in slopes and symmetry in the curvatures, therefore confirming the accuracy of the measurements. Significant correlations between two models in the curvatures allow us to assume that the OCT retinal shape can be used for the assessment of the off-axis refraction.
This is a 2021 ARVO Annual Meeting abstract.