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Jinhua Bao, Yingying Huang, XUE LI, Adeline Yang, Ee Woon Lim, Daniel Spiegel, Bjorn Drobe, Hao Chen; Myopia control with spectacle lenses with aspherical lenslets: a 2-year randomized clinical trial. Invest. Ophthalmol. Vis. Sci. 2021;62(8):2888.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the myopia control efficacy of two new designs of spectacle lenses with concentric rings of contiguous aspherical lenslets in a 2-year clinical trial.
One hundred and seventy Chinese children (aged 8 to 13 years old, myopia between -0.75D and -4.75D) with myopia were randomly assigned to wear one of the three spectacle lenses: spectacle lenses with highly aspherical lenslets (HAL), spectacle lenses with slightly aspherical lenslets (SAL), or control single-vision lenses (SVL) for 2 years. Spherical equivalent of cycloplegic autorefraction (SER) and axial length (AL) were measured on a six-monthly basis. Wearing time was assessed using a questionnaire at each visit.
A total of 157 children completed the 2-year study, of which, 54, 53, and 50 were in the HAL group, SAL group, and SVL group, respectively. After 2 years, the mean SER and AL (± SEM) of the SVL control group increased by -1.46 ± 0.60 D and 0.69 ± 0.26 mm, respectively. Compared with SVL, spectacle lenses with aspherical lenslets significantly slowed myopia progression (HAL, -0.66 ± 0.08 D, difference 0.80 D; SAL, -1.04 ± 0.06 D, difference 0.42 D) and axial elongation (HAL, 0.34 ± 0.03 mm, difference 0.35 mm; SAL, 0.51 ± 0.03 mm, difference 0.18 mm; all p<0.001). In children who wore their lenses every day for at least 12 hours per day, the reduction in SER and AL, compared to SVL group, was greater at 0.99 D (p<0.001) and 0.41 mm (p=0.03) for HAL (n=32) and at 0.57 D (p=0.04) and 0.26 mm (p=0.02) for SAL (n=28), respectively.
Spectacle lenses with aspherical lenslets were effective in slowing myopia progression and axial elongation in children over a two-year period, compared with SVL. Myopia control efficacy was higher in children who wore their lenses full-time (≥12 hours/day) and spectacle lenses with highly aspherical lenslets.
This is a 2021 ARVO Annual Meeting abstract.
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