June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
High-risk Histopathologic Features of Primarily Enucleated Retinoblastoma
Author Affiliations & Notes
  • Xiaolin Xu
    Beijing Institute of Ophthalmology, Beijing Tongren Hospital, China
  • Xu Zhang
    Beijing Institute of Ophthalmology, Beijing Tongren Hospital, China
  • Fei Gao
    Beijing Institute of Ophthalmology, Beijing Tongren Hospital, China
  • Zhibao Zhang
    Beijing Institute of Ophthalmology, Beijing Tongren Hospital, China
  • Footnotes
    Commercial Relationships   Xiaolin Xu, None; Xu Zhang, None; Fei Gao, None; Zhibao Zhang, None
  • Footnotes
    Support  National Natural Science Foundation of China #8150234
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 2856. doi:
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    • Get Citation

      Xiaolin Xu, Xu Zhang, Fei Gao, Zhibao Zhang; High-risk Histopathologic Features of Primarily Enucleated Retinoblastoma. Invest. Ophthalmol. Vis. Sci. 2021;62(8):2856.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the high-risk histopathologic features (HRFs) of retinoblastoma (RB) eyes enucleated as the primary treatment strategy.

Methods : A retrospective histopathological analysis of HRFs was performed. A total of 950 primarily enucleated RB eyes from Beijing Tongren Hospital were analyzed.

Results : Of the 950 primarily enucleated RB eyes, 362(38.1%) were classified as HRFs, of which 287 (30.2%) had post lamina cribrosa optic nerve invasion (including 32 (3.4%) with optic nerve transection invasion), 133 (14.0%) with massive choroidal invasion, 58 (6.1%) with anterior segment invasion, and 12(1.3%) with extraocular invasion. NVI was identified in 508 patients (53.5%) and was significantly correlated with HRFs. The proportion of HRFs was significantly higher in the NVI-positive group (50.6%) compared to the NVI-negative group (23.8%) (P<0.001). The proportion of post lamina cribrosa optic nerve invasion was significantly higher in the NVI-positive group (44.1%) compared to the NVI-negative group (14.3%) (P<0.001). The proportion of massive choroidal invasion was significantly higher in the NVI-positive group (18.9%) compared to the NVI-negative group (10.6%) (P<0.001).

Conclusions : HRFs occurred in slightly more than one-third of RB cases, which was similar to HRFs incidence in developing countries and higher than that in developed countries. To a certain degree NVI is a predictor of HRFs. When considering primary treatment, especially intra-artery chemotherapy (IAC), the facts that more than one-third of RB eyes have HRFs and a little more than half of NVI-positive RB eyes have HRFs should be carefully thought out.

This is a 2021 ARVO Annual Meeting abstract.

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