Epidemiologic Analysis of Mucinous Adenocarcinoma of the Eyelid: A Population-Based Analysis, 2000-2017

Abstract

Purpose : There are limited studies on mucinous adenocarcinoma of the eyelid (MAE) in the literature. Using a large database, we explore the epidemiologic trends of this entity.

Methods : A retrospective, population-based analysis was conducted using the Surveillance, Epidemiology, and End Results Registry. All patients diagnosed with MAE from 2000-2017 were included. Incidence rate (IR) was calculated in number of cases/million/year. Overall survival (OS) was calculated using the Kaplan-Meier method.

Results : 222 cases were identified, 58.1% of whom were female and 73.8% were white. Overall IR of MAE was 0.14. Annual percent change was 7.34 (p<0.001). There was no difference in IR between males (0.13) and females (0.14) [p=0.34]. IR in the black race (0.247) was significantly higher than in the white (0.12) [p<0.001] and in the Asian/Pacific Islander (0.10) [p<0.001] races. IR in patients older than 65 years old (y/o) [0.74] was significantly higher than in those 22-64 y/o (0.083) [p <0.001] or in those younger than 21 y/o (0.002) [p<0.001]. Stratification based on stage showed that 78.1 % of cases were localized, 4.5 % were regional and 17.4 % were distant. Only 1 bilateral case was identified and the rest of the cases were unilateral.

Conclusions : Mucinous adenocarcinoma of the eyelid incidence is highest in the elderly and black populations and is not affected by sex. Incidence is increasing over the timeframe studied. Most of the cases are diagnosed at a localized stage.

This is a 2021 ARVO Annual Meeting abstract.