June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Association of OCT imaging parameters with longitudinal changes in cognition in older adults participating in the Atherosclerosis Risk in Communities (ARIC) study
Author Affiliations & Notes
  • Pradeep Y Ramulu
    Ophthalmology, Johns Hopkins Medicine, Baltimore, Maryland, United States
  • Xinxing Guo
    Ophthalmology, Johns Hopkins Medicine, Baltimore, Maryland, United States
  • Richey A Sharrett
    Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States
  • Aleksandra Mihailovic
    Ophthalmology, Johns Hopkins Medicine, Baltimore, Maryland, United States
  • Lubaina Tayeb Arsiwala
    Ophthalmology, Johns Hopkins Medicine, Baltimore, Maryland, United States
  • Alison Abraham
    Ophthalmology, University of Colorado, Denver, Colorado, United States
  • Footnotes
    Commercial Relationships   Pradeep Ramulu, None; Xinxing Guo, None; Richey Sharrett, None; Aleksandra Mihailovic, None; Lubaina Arsiwala, None; Alison Abraham, None
  • Footnotes
    Support  NIH AG052412
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 2833. doi:
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      Pradeep Y Ramulu, Xinxing Guo, Richey A Sharrett, Aleksandra Mihailovic, Lubaina Tayeb Arsiwala, Alison Abraham; Association of OCT imaging parameters with longitudinal changes in cognition in older adults participating in the Atherosclerosis Risk in Communities (ARIC) study. Invest. Ophthalmol. Vis. Sci. 2021;62(8):2833.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Previous cross-sectional studies have demonstrated a thinner retinal nerve fiber layer (rNFL) and macular ganglion cell complex (GCC) in persons with Alzheimer’s Disease/cognitive impairment. Here, we examine the association of these OCT parameters with longitudinal changes in cognition in a biracial population-based sample of older adults participating in the Atherosclerosis Risk in Communities (ARIC) study.

Methods : Non-demented Black ARIC participants from Jackson, MS, and White ARIC participants from Washington County, MD, were enrolled in the Eye Determinants of Cognition (EyeDOC) study, in which peripapillary and macular OCT imaging was performed on a randomly selected eye between 2017 and 2019. Changes in cognition were derived from a 10-test neurocognitive battery administered to each participant three times between 2011 and 2020. Primary analyses examined the association of rNFL and GCC thickness with longitudinal changes in global cognition in the full cohort, using linear mixed effect models incorporating spline terms, adjusting for age, sex, education, smoking history, hypertension, diabetes, physical activity, and intraocular pressure. Additional analyses examined change within cognitive domains (memory, executive function and language) and were stratified for participants at each study site.

Results : A total of 914 participants (407 from Jackson; 507 from Washington County) had adequate OCT imaging and complete cognitive data. Mean participant age was 74 years at the initial cognitive examination and 64% were female. Neither GCC thickness (p=0.53) nor rNFL thickness (p=0.76) was associated with a greater rate of decline in global cognition scores. Likewise, neither GCC nor rNFL thickness were associated with the rate of decline in the memory, executive function, or language domains (p>0.4 for all). Similar results were observed when analyses were stratified for Jackson and Washington County participants.

Conclusions : In this biracial cohort of non-demented older adults, lower rNFL and GCC thickness was not associated with declines in cognition. These results suggest that OCT parameters may not have utility in predicting the risk of future cognitive decline in all populations.

This is a 2021 ARVO Annual Meeting abstract.

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