June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Effect of short-term peripheral myopic defocus on ocular biometrics using Fresnel “press-on” lenses in human subjects
Author Affiliations & Notes
  • Ryo Kubota
    Kubota Vision Inc., Seattle, Washington, United States
  • Nabin R Joshi
    Manhattan Vision Associates/Institute for Vision Research, New York, New York, United States
  • Inna Samandarova
    Manhattan Vision Associates/Institute for Vision Research, New York, New York, United States
  • Maksud Oliva
    Manhattan Vision Associates/Institute for Vision Research, New York, New York, United States
  • Arkady Selenow
    Manhattan Vision Associates/Institute for Vision Research, New York, New York, United States
  • Amitava Gupta
    Kubota Vision Inc., Seattle, Washington, United States
  • Steven R Ali
    Manhattan Vision Associates/Institute for Vision Research, New York, New York, United States
  • Footnotes
    Commercial Relationships   Ryo Kubota, Kubota Vision Inc. (E); Nabin Joshi, None; Inna Samandarova, None; Maksud Oliva, None; Arkady Selenow, Kubota Vision Inc. (F); Amitava Gupta, Kubota Vision Inc. (E); Steven Ali, Kubota Vision Inc. (F)
  • Footnotes
    Support  Kubota Vision Inc.
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 2746. doi:
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      Ryo Kubota, Nabin R Joshi, Inna Samandarova, Maksud Oliva, Arkady Selenow, Amitava Gupta, Steven R Ali; Effect of short-term peripheral myopic defocus on ocular biometrics using Fresnel “press-on” lenses in human subjects. Invest. Ophthalmol. Vis. Sci. 2021;62(8):2746.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : This study aimed to assess axial length and choroidal thickness changes following short-term peripheral myopic defocus sessions.

Methods : 20 visually-normal subjects (13 females and 7 males) of mean age 25.5 years (range 19-31) with mean spherical equivalent refractive error of -2.02 D (range 0 to -4.13 D, cyl < 0.75 D) were enrolled. 14 subjects were Asian and 6 were Caucasian. Subjects underwent defocus sessions by watching projected (ViewSonix PX706 projector) color movies (screen dimensions: 8 ft H X 12 ft W) 4 meters away under controlled conditions (room illumination of approximately 80 lux) while wearing standard spectacle lenses corrected for distance refraction (both eyes) for 4 hours between 8:00 am to 12:00 pm. The right (test) eye was peripherally defocused using a Fresnel lens overlay of +3.50D with a central clear aperture of 15 degree diameter, which was centered for the subject’s pupillary axis on primary gaze, while the fully-corrected left eye served as the control. A subset of 10 subjects from the same cohort also further underwent similar defocus sessions with +5.00D of peripheral defocus supplied through the Fresnel lenses on a different day following a wash-out of at least 1 day. Axial length was measured with a Lenstar APS 900 from Haag-Streit Holding, and radial choroidal scans were obtained from Heidelberg SD-OCT with EDI, before and after the defocus sessions.

Results : The test eye was approximately 11 µm shorter than the control eye when measured after 4 hours of defocus for both +3.50D and +5.00 D peripheral myopic defocus conditions (corrected p<0.05). The thickening of choroidal thickness after defocus was more robust for the +5.00D condition compared to the +3.50 condition (p>0.05 for both conditions).

Conclusions : We have shown, for the first time, that short-term peripheral myopic defocus is capable of inhibiting eye-elongation, which gives additional insight towards the physiological effect of peripheral myopic defocus.

This is a 2021 ARVO Annual Meeting abstract.

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